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SAB4300488

Sigma-Aldrich

Anti-FGFR1 (Ab-154) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-BFGFR antibody produced in rabbit, Anti-CD331 antibody produced in rabbit, Anti-CEK antibody produced in rabbit, Anti-FGFBR antibody produced in rabbit, Anti-fibroblast growth factor receptor 1 antibody produced in rabbit

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~145 kDa

Espèces réactives

human, mouse

Concentration

1 mg/mL

Technique(s)

western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(A-P-Y-W-T)

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... FGFR1(2260)

Description générale

FGFR1 (fibroblast growth factor receptor 1) gene codes for 9 isoforms of FGFR1. It has 19 exons spanning 55kb DNA. It is located on human chromosome 8p11.1. High level expression of FGFR1 is seen in midfacial membranous ossification sites. It is mostly present in neurons like hippocampal and dentate gyrus neurons.

Immunogène

Peptide sequence around aa. 152-156 (A-P-Y-W-T), according to the protein FGFR1.

Application

Anti-FGFR1 (Ab-154) antibody has been used in western blotting .

Actions biochimiques/physiologiques

FGFR1 (fibroblast growth factor receptor 1) helps in the growth of nervous system. It also controls the skeletal development and bone homeostasis. FGFR1 mutations lead to craniosynostosis and facial abnormalities. Mutation in FGFR1 Ig-like domain II-III linker region (FGFR1 P252R) results in Pfeiffer syndrome.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

FGF encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR
Makani V, et al.
PLoS ONE, 11(3) (2016)
Contribution of FGFR1 Variants to Craniofacial Variations in East Asians
Adel M, et al.
PLoS ONE, 12(1) (2017)
Vishruti Makani et al.
PloS one, 11(3), e0149715-e0149715 (2016-03-05)
An enormous amount of efforts have been poured to find an effective therapeutic agent for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). Among those, neurotrophic peptides that regenerate neuronal structures and increase neuron survival show a promise in

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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