SAB4200429

Anti-PIWIL4 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-HIWI2, Anti-MIWI2, Anti-Piwi-like 4
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~95 kDa
• Espèces réactives: human
• Concentration: ~1.0 mg/mL
• Technique(s): western blot: 0.5-1.0 μg/mL using lysates of HEK-293Tcells overexpressing human PIWIL4.
• Numéro d'accès UniProt: Q7Z3Z4
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PIWIL4(143689)

Description

Description générale

P-element Induced WImpy testis (PIWI)-like 4 (PIWIL4) protein belongs to the PIWI subfamily. This protein is localized in tumorous colon tissues. PIWIL4 gene is located on the human chromosome at 11q21.

Spécificité

Anti-PIWIL4 recognizes human PIWIL4.

Immunogène

peptide corresponding to an internal region of human PIWIL4, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat.

Application

Anti-PIWIL4 antibody produced in rabbit may be used in immunoblotting.

Actions biochimiques/physiologiques

P-element Induced WImpy testis (PIWI)-like 4 (PIWIL4) protein promotes tumorigenesis and cell invasion. It is expressed in several cancers like colon and breast cancer. This protein enhances cell growth and blocks apoptosis in cervical cancer cells. PIWIL4 protein is also involved in the chromatin-modifying pathway of human somatic cells. Mutation in the PIWIL4 gene is associated with breast cancer.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable