SAB3500816

Anti-CMPK2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: predicted mol wt 49 kDa
• Espèces réactives: mouse, rat, human
• Technique(s): ELISA: suitable; immunofluorescence: suitable; western blot: suitable
• Numéro d'accès UniProt: Q5EBM0
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CMPK2(129607)

Description

Description générale

Cytidine/uridine monophosphate kinase 2 (CMPK2) is expressed in mitochondria. The protein Cmpk2 is similar to thymidylate kinase than to cytosolic Cmpk1. Cmpk2 has thymidylate kinase domain and the C-terminal domain contains all the consensus motifs: P-loop (ATP/ GTP binding motif A), LID (domain in lipase) domain, adenine-base binding loop, catalytic site, and potential substrate binding site. In human chromosome, the gene is localized on 2p25.2.

Actions biochimiques/physiologiques

Cmpk2 utilizes ATP (adenosine triphosphate) as phosphate donor to phosphorylate dUMP (deoxyuridine monophosphate), dCMP (deoxycytidine monophosphate), CMP (cytosine monophosphate), and UMP (uridine monophosphate). The order of substrate specificity for Cmpk2 is UMP, the highest, followed by dCMP, CMP and UMP. Cmpk2 also phosphorylates monophosphate nucleoside analogs ddC (zalcitabine), dFdC (gemcitabine), araC (vidarabine), BVDU (brivudine), and FdUrd (fluorodeoxyuridine). Cmpk2 expression is found in leukemic cells like chronic myelogenous leukemia K-562 and lymphoblastic leukemia MOLT-4, implicates its pathophysiology. The catalytic activity of Cmpk2 is similar to human adenylate kinase 9.

Caractéristiques et avantages

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Liaison

The action of this antibody can be blocked using blocking peptide SBP3500816.

Forme physique

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable