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S9318

Sigma-Aldrich

Sandoz 58-035

>98% (HPLC), powder, acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor

Synonyme(s) :

3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenethyl]propanamide, SA 58-035

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About This Item

Formule empirique (notation de Hill):
C30H47NOSi
Numéro CAS:
78934-83-5
Poids moléculaire :
465.79
Numéro MDL:
MFCD00161339
Code UNSPSC :
41121801
ID de substance PubChem :
24278227
Nomenclature NACRES :
NA.77

product name

Sandoz 58-035, >98% (HPLC), powder

Niveau de qualité

100

Pureté

>98% (HPLC)

Forme

powder

Couleur

white

Solubilité

DMSO: 16 mg/mL
H2O: insoluble

Auteur

Novartis

Température de stockage

2-8°C

Chaîne SMILES 

CCCCCCCCCC[Si](C)(C)CCC(=O)NC(Cc1ccc(C)cc1)c2ccccc2

InChI

1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)

Clé InChI

NBYATBIMYLFITE-UHFFFAOYSA-N

Informations sur le gène

human ... SOAT1(6646)
rat ... Soat1(81782)

Application

Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages.3

Actions biochimiques/physiologiques

Sandoz 58-035 inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture.1 It does not affect the triglyceride metabolism by the gut.2
Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Hiroshi Hirata et al.
The Journal of nutritional biochemistry, 47, 29-34 (2017-05-16)
Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important
Shizuya Yamashita et al.
Journal of clinical lipidology, 12(5), 1267-1279 (2018-08-06)
Cardiovascular risk is negatively correlated with cholesterol efflux capacity (CEC) from macrophages to high-density lipoproteins (HDLs) and positively correlated with fasting and nonfasting triglyceride-rich lipoproteins (TRLs). Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator, robustly decreases the fasting TRL
Shelley J Edmunds et al.
Scientific reports, 10(1), 18070-18070 (2020-10-24)
Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) induces glucose uptake by muscle tissues and stimulates pancreatic insulin secretion, and also facilitates cholesterol transport in circulation, and is explored for anti-diabetic and anti-atherosclerotic treatments. As the better alternative to complex protein-lipid
H Hakamata et al.
Arteriosclerosis and thrombosis : a journal of vascular biology, 14(11), 1860-1865 (1994-11-01)
The species difference in the turnover rates of the cholesteryl ester (CE) cycle in macrophage foam cells (MFC) was examined in mice and rats. MFC were induced by acetyl-LDL and pulsed with [3H]oleate, followed by a chase with [14C]oleate. The
K Cianflone et al.
Atherosclerosis, 107(2), 125-135 (1994-06-01)
This study examines the effects of extracellular albumin on hepatic apo B-100 metabolism. To do so, a transformed human liver cell line, HepG2, was used as a hepatocyte model and the concentration of albumin in the medium was varied between
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