S5269
Serum amyloid P component human
buffered aqueous solution
Synonyme(s) :
Amyloid P component from serum
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About This Item
Produits recommandés
Forme
buffered aqueous solution
Niveau de qualité
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Informations sur le gène
human ... APCS(325)
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Application
Human serum amyloid P component has been used as a standard in a study to characterize it as a plasma marker for Parkinson′s disease by a proteomic approach.
Actions biochimiques/physiologiques
Serum amyloid P component (SAP) is named for its universal presence in amyloid deposits (senile plaque and neurofibrillary tangles) in Alzheimer patients although it is exclusively synthesized in the periphery. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A beta deposition since no endogenous SAP immunoreactivity was detectable in transgenic mouse overexpressing beta-protein precursor. SAP belongs to the pentraxins family of oligomeric serum proteins which is highly conserved through evolution. Its presence has been found in Limulus polyphemus haemolymph. A recent report demonstrated that, in the presence of calcium, SAP can bind to free DNA and chromatin released through apoptosis or necrosis, displacing histone H1 and causing its solubilization and degradation. SAP knock out mice developed antinuclear autoimmunity and glomerulonephritis. However, the protective role of SAP in human SLE is still controversial. In addition, SAP neutralizes LPS and is potentially useful in defense against serious gram-negative sepsis in humans.
Forme physique
Solution in 0.01 M Tris, 0.14 M NaCl at pH 8.0 containing 0.01 M EDTA and 0.1% (w/v) NaN3
Clause de non-responsabilité
Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d'importation et d'exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L'acheteur (c'est-à-dire l'utilisateur final) est tenu d'obtenir une autorisation d'importation auprès du Ministère français de la Recherche, mentionné à l'article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l'autorisation d'importation requise.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Amyloid P component as a plasma marker for Parkinson's disease identified by a proteomic approach
Han-Min Chen
Clinical Biochemistry (2011)
New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein.
C J de Haas
FEMS immunology and medical microbiology, 26(3-4), 197-202 (1999-11-27)
Serum amyloid P component (SAP) is a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. Although SAP is described to bind many ligands, no clear biological function has been ascribed to it as yet. This review
C J de Haas et al.
Infection and immunity, 67(6), 2790-2796 (1999-05-25)
Lipopolysaccharide (LPS) is the major mediator of gram-negative septic shock. Molecules that bind LPS and neutralize its toxic effects could have important clinical applications. We showed that serum amyloid P component (SAP) neutralizes LPS. A SAP-derived peptide, consisting of amino
M Kimura et al.
Neuroscience letters, 273(2), 137-139 (1999-10-03)
Serum amyloid P component (SAP) is a normal plasma constituent that is observed both in senile plaque and in neurofibrillary tangle in brains of patients with Alzheimer's disease (AD). In this study, we evaluated the SAP levels in cerebrospinal fluid
M C Bickerstaff et al.
Nature medicine, 5(6), 694-697 (1999-06-17)
Serum amyloid P component (SAP), a highly conserved plasma protein named for its universal presence in amyloid deposits, is the single normal circulating protein that shows specific calcium-dependent binding to DNA and chromatin in physiological conditions. The avid binding of
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