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S4701

Sigma-Aldrich

Suplatast tosylate

≥98% (HPLC)

Synonyme(s) :

(+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate, IPD-1151T, ST

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About This Item

Formule empirique (notation de Hill):
C16H26SNO4 · C7H7SO3
Numéro CAS:
94055-76-2
Poids moléculaire :
499.64
Numéro MDL:
MFCD00867604
Code UNSPSC :
12352200
ID de substance PubChem :
329824551
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

DMSO: >20 mg/mL

Température de stockage

room temp

Chaîne SMILES 

Cc1ccc(cc1)S([O-])(=O)=O.CCOCC(O)COc2ccc(NC(=O)CC[S+](C)C)cc2

InChI

1S/C16H25NO4S.C7H8O3S/c1-4-20-11-14(18)12-21-15-7-5-13(6-8-15)17-16(19)9-10-22(2)3;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,14,18H,4,9-12H2,1-3H3;2-5H,1H3,(H,8,9,10)

Clé InChI

RYVJQEZJUFRANT-UHFFFAOYSA-N

Application

Suplatast tosylate may be used in immune-signaling studies.

Actions biochimiques/physiologiques

Suplatast tosylate is a dimethylsulfonium compound downregulates the expression of histamine H1 receptor gene, suppresses the activity of histidine decarboxylase and regulates IL-4 mRNA. It inhibits the release of histamines and regulates the production of IgE.1,2 Suplatast tosylate is effective in the treatment of mild-to-moderate persistent asthma in children.3
Suplatast tosylate is an anti-allergy, cytokine modulator.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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S Fatemeh Mousavi et al.
Bioorganic chemistry, 90, 103037-103037 (2019-06-19)
Capecitabine as a prodrug of 5-Fluorouracil plays an important role in the treatment of breast and gastrointestinal cancers. Herein, in view of the importance of this drug in chemotherapy, interaction mechanism between Capecitabine (CAP) and human serum albumin (HSA) as
Sandhir B Prasad et al.
The American journal of cardiology, 124(3), 325-333 (2019-06-04)
The inter-relationships between minimal and maximal left atrial volume index (LAVI), left ventricular filling pressures and survival have not been well studied. This study aimed to compare LAVImin with LAVImax with respect to (1) relative prognostic value, and (2) correlation
Vitor Hugo Bezerra et al.
Sensors (Basel, Switzerland), 19(14) (2019-07-25)
Internet of Things (IoT) devices have become increasingly widespread. Despite their potential of improving multiple application domains, these devices have poor security, which can be explored by attackers to build large-scale botnets. In this work, we propose a host-based approach
Flemming K Nielsen et al.
BMC musculoskeletal disorders, 18(1), 510-510 (2017-12-06)
To evaluate whether clinical, radiographic or MRI findings are associated with long term risk for total knee arthroplasty (TKA) in persons with knee osteoarthritis. We performed a follow-up analysis of 100 persons with knee osteoarthritis who participated in a clinical
Roberta W Scherer et al.
JAMA otolaryngology-- head & neck surgery, 145(7), 597-608 (2019-05-24)
Tinnitus retraining therapy (TRT) is an internationally recognized, but controversial, protocol of uncertain efficacy that uses tinnitus-specific educational counseling (TC) and sound therapy (ST) to reduce the patient's tinnitus-evoked negative reaction to, and awareness of, tinnitus. To compare the efficacy
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