PZ0195

CYP3cide

≥98% (HPLC)

• Synonyme(s) : 1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, PF-04981517
• Formule empirique (notation de Hill) : C₂₆H₃₂N₈
• Numéro CAS: 1390637-82-7
• Poids moléculaire : 456.59
• Numéro MDL: MFCD22417344
• Code UNSPSC : 12161501
• ID de substance PubChem : 329823769
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: >10 mg/mL (warmed)
• Température de stockage: room temp
• Chaîne SMILES: Cc1ccc(cc1)-c2c(cnn2C)-c3nn(C)c4ncnc(N5CC[C@@H](C5)N6CCCCC6)c34
• InChI: 1S/C26H32N8/c1-18-7-9-19(10-8-18)24-21(15-29-31(24)2)23-22-25(32(3)30-23)27-17-28-26(22)34-14-11-20(16-34)33-12-5-4-6-13-33/h7-10,15,17,20H,4-6,11-14,16H2,1-3H3/t20-/m0/s1
• Clé InChI: WDWIMDKOXZZYHH-FQEVSTJZSA-N

Description

Actions biochimiques/physiologiques

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4 that can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism. The IC₅₀ values for inhibition of Midazolam 1′-Hydroxylase activity of recombinant CYP3A4 and CYP3A5 by CYP3cide are 0.3 and 17 mM, respectively.

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations légales

Sold for research purposes under agreement from Pfizer Inc.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable