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PZ0124

Sigma-Aldrich

CP-66713

≥98% (HPLC)

Synonyme(s) :

8-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine, PF-1716311

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About This Item

Formule empirique (notation de Hill):
C15H10ClN5
Numéro CAS:
91896-57-0
Poids moléculaire :
295.73
Numéro MDL:
MFCD17215961
Code UNSPSC :
51111800
ID de substance PubChem :
329823714
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

DMSO: ≥5 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Nc1nc2ccc(Cl)cc2n3c(nnc13)-c4ccccc4

InChI

1S/C15H10ClN5/c16-10-6-7-11-12(8-10)21-14(9-4-2-1-3-5-9)19-20-15(21)13(17)18-11/h1-8H,(H2,17,18)

Clé InChI

PBENJWAFQLORQL-UHFFFAOYSA-N

Actions biochimiques/physiologiques

CP-66713 is an adenosine A2 receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

E M O'Kane et al.
European journal of pharmacology, 362(1), 17-25 (1998-12-29)
Previous work has been carried out on the effects of adenosine on transmitter release and on the excitability of postsynaptic neurones, but little is known about the effects of adenosine on the coupling between the two. In this study, we
S Fujii et al.
Neuroscience letters, 148(1-2), 148-150 (1992-12-14)
The effects of the adenosine A2 receptor antagonist CP-66713 on the reversal of long-term potentiation (LTP) were studied in CA1 neurons of guinea pig hippocampal slices. Reduction of LTP (depotentiation, DP) was effected by delivering a train of low-frequency afferent
T Matsugi et al.
Investigative ophthalmology & visual science, 38(13), 2695-2701 (1998-01-07)
To investigate the effect of adenosine on the contractile tone of cultured bovine retinal pericytes. Changes in the contractile tone were quantified as the changes in the summed length of wrinkles induced by pericytes on the silicone surface on which
B B Fredholm et al.
European journal of pharmacology, 380(2-3), 197-202 (1999-10-08)
We have examined the potency of several adenosine receptor antagonists at adenosine A1 and A2A receptors using quantitative autoradiography and have compared the results with those of previous studies using the same radioligands in membrane preparations. The agonists [3H]cyclohexyladenosine and
Y Sekino et al.
Biochemical and biophysical research communications, 181(3), 1010-1014 (1991-12-31)
The effects of adenosine A2 receptor antagonist (CP-66713) on long-term potentiation were studied using guinea pig hippocampal slices in a perfusion system. Tetanic stimulation of Schaffer collateral input which was applied during perfusion of CP-66713 (10 microM), did not induce
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