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P1784

Sigma-Aldrich

Pentoxifylline

solid

Synonyme(s) :

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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About This Item

Formule empirique (notation de Hill):
C13H18N4O3
Numéro CAS:
6493-05-6
Poids moléculaire :
278.31
Numéro CE :
229-374-5
Numéro MDL:
MFCD00063379
Code UNSPSC :
41106305
ID de substance PubChem :
24278190
Nomenclature NACRES :
NA.77

Forme

solid

Niveau de qualité

100

Couleur

white

Solubilité

H2O: ≥43 mg/mL, colorless to almost colorless

Auteur

Sanofi Aventis

Chaîne SMILES 

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

Clé InChI

MQGNNJQTNFHNHK-UHFFFAOYSA-N

Informations sur le gène

human ... ADORA2B(136) , LITAF(9516) , PDE4B(5142) , TNF(7124)
rat ... Tnf(24835)

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Application

Pentoxifylline has been used:
  • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
  • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
  • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

Actions biochimiques/physiologiques

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H362

Classification des risques

Acute Tox. 4 Oral - Lact.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

PP-023-Effect of ICSI with `pentoxifylline exposed sperms? on subsequent embryo development
Mangoli V S, et al.
Reproductive Biomedicine Online, 32, S11-S11 (2016)
B K Reuter et al.
The American journal of physiology, 277(4 Pt 1), G847-G854 (1999-10-12)
Although the ability of nonsteriodal anti-inflammatory drugs (NSAIDs) to injure the small intestine has been well established in humans and animals, the mechanism involved in this type of injury has yet to be elucidated. The cytokine tumor necrosis factor-alpha (TNF-alpha)
Maria Del Mar Castro et al.
Pathogens (Basel, Switzerland), 11(3) (2022-03-27)
Addition of the immunomodulator pentoxifylline (PTX) to antimonial treatment of mucosal leishmaniasis has shown increased efficacy. This randomized, double-blind, placebo-controlled trial evaluated whether addition of pentoxifylline to meglumine antimoniate (MA) treatment improves therapeutic response in cutaneous leishmaniasis (CL) patients. Seventy-three
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
Naranjo T W, et al.
Pulmonary Pharmacology & Therapeutics, 24(1), 81-91 (2011)
Pentoxifylline Enhances the Apoptotic Effect of Carboplatin in Y79 Retinoblastoma Cells
CRUZ-GALVEZ C C, et al.
In Vivo, 33(2), 401-412 (2019)
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