MSQC10
SILu™MAb Mouse Stable-Isotope Labeled Monoclonal Antibody
from mouse, recombinant, expressed in CHO cells
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.12
Produits recommandés
Source biologique
mouse
Produit recombinant
expressed in CHO cells
Type de produit anticorps
primary antibodies
Pureté
≥90% (SDS-PAGE)
Conditionnement
vial of 100 μg
Conditions d'expédition
wet ice
Température de stockage
−20°C
Catégories apparentées
Description générale
SILu™MAb Mouse is a recombinant, stable isotope-labeled, mouse monoclonal antibody which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, SILu™MAb Mouse is designed to be used as a universal internal standard for bioanalysis of monoclonal murine antibodies in animal pharmacokinetics (PK) studies.
SILu™MAb Mouse is an IgG1 antibody with a kappa light chain. Because of overlap with common sequences in the Fc region with candidate murine antibodies, SILu™MAb Mouse provides universal utility, and thus, eliminates the need to produce candidate-specific internal standards.
SILu™MAb Mouse is an IgG1 antibody with a kappa light chain. Because of overlap with common sequences in the Fc region with candidate murine antibodies, SILu™MAb Mouse provides universal utility, and thus, eliminates the need to produce candidate-specific internal standards.
Forme physique
Each vial of SILu™MAb Mouse contains the labeled antibody lyophilized from a solution of phosphate buffered saline. Vial content was determined by measuring A280 and using an extinction coefficient (E0.1%) of 1.4.
Notes préparatoires
Produced utilizing enriched media containing stable isotope labeled amino acids such as [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, SILuMAb Mouse is designed to be used as a universal internal standard for bioanalysis of monoclonal murine antibodies in animal pharmacokinetics (PK) studies
Reconstitution
SILu™MAb Mouse recovery is maximized when 0.1% formic acid is used for reconstitution of the lyophilized product.
Reconstitution with other solvents may reduce recovery. Do not freeze after reconstitution.
Reconstitution with other solvents may reduce recovery. Do not freeze after reconstitution.
- Briefly centrifuge the vial at ~10,000 × g to collect the product at the bottom of the vial.
- Add 500 μL of ultrapure water containing 0.1% formic acid to the vial.
- Mix the contents by gently inverting the vial a minimum of 5 times.
- Allow the vial to stand at room temperature for at least 15 minutes and repeat mixing by inversion.
Informations légales
SILu is a trademark of Sigma-Aldrich Co. LLC
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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