The kit MAK157 does not contain any Renin inhibitor. To confirm the activity using this kit, researchers can use a RENIN INHIBITOR separately.The amount of inhibitor to use and the step to use the Renin inhibitor can be referred to from published literature.
MAK157
Renin Assay Kit
Renin Assay Kit
1 of 1 reviewers received a sample product or took part in a promotion
sufficient for 100 fluorometric tests
Synonyme(s) :
Renin Enzyme Detection Kit
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283.00 CHF
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1 KIT
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About This Item
Code UNSPSC :
12161503
Nomenclature NACRES :
NA.84
Produits recommandés
Utilisation
sufficient for 100 fluorometric tests
Méthode de détection
fluorometric
Maladie(s) pertinente(s)
cardiovascular diseases
Température de stockage
−20°C
Informations sur le gène
human ... REN(5972)
rat ... REN(24715)
Catégories apparentées
Description générale
Renin, also known as angiotensinogenase, is an aspartyl protease that cleaves angiotensinogen to form angiotensin I, the initial and rate-limiting step of the renin-angiotensin system (RAS). This system plays a critical role in the regulation of blood pressure and fluid balance. Increased renin activity can result in hypertension due to increased vasoconstriction and fluid retention. Inhibitors of renin can be used as a treatment for hypertension.[1]
Adéquation
The Renin Assay Kit provides a convenient and simple method for screening renin activity in a variety of samples or for screening renin inhibitors.
Principe
Renin activity is determined using a proprietary fluorescence resonance energy transfer (FRET) peptide containing a fluorescence quencher. Cleavage of the peptide by renin results in the production of a fluorescent product (λex = 540/λem = 590 nm). This assay is ~50-fold more sensitive than the EDANS/DABCYL-based assay.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Árpád Kovács et al.
American journal of physiology. Heart and circulatory physiology, 310(11), H1671-H1682 (2016-04-10)
Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin overexpressing rats (carrying mouse Ren-2 renin gene, mRen2, n = 6). Blood pressure (BP) was measured.
Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells.
Sim?o S, et al.
Angiogenesis, 20(1), 175-181 (2017)
The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol.
Song P, et al.
Cell Metabolism, 27(6), 1338-1347 (2018)
Caroline G Shimoura et al.
Journal of applied physiology (Bethesda, Md. : 1985), 128(5), 1329-1337 (2020-04-03)
Acute intermittent hypoxia (AIH) triggers sympathetic long-term facilitation (sLTF), a progressive increase in sympathetic nerve activity (SNA) linked to central AT1 receptor (AT1R) activation by circulating angiotensin II (ANG II). Here, we investigated AIH activation of the peripheral renin-angiotensin system
Yoshio T, et al.
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research (2015)
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Does the kit MAK157 contain any Renin inhibitor? If so, how much Renin inhibitor should be added, and at what step of the assay should it be added in order to determine the Renin activity?
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