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M2922

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Name: 3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Brand: SIGMA

Synonyme(s) :

CL 218,872

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About This Item

Formule empirique (notation de Hill):

C₁₃H₉F₃N₄

Numéro CAS:

66548-69-4

Poids moléculaire :

278.23

Numéro MDL:

MFCD00674912

Code UNSPSC :

12352200

ID de substance PubChem :

24278545

Température de stockage

2-8°C

Chaîne SMILES

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

Informations sur le gène

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRG2(2566)

Actions biochimiques/physiologiques

Selective agonist at the BZ_I benzodiazepine receptor.

Pictogrammes

GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Conseils de prudence

P261 - P305 + P351 + P338

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Bicyclic [b]-heteroannulated pyridazine derivatives--II. Structure-activity relationships in the 6-aryltriazolo-[4,3-b]pyridazine ligands of the benzodiazepine receptor.

J Karolak-Wojciechowska et al.

Bioorganic & medicinal chemistry, 2(8), 773-779 (1994-08-01)

Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) were calculated by semiempirical quantum chemistry methods for 2 sets (X = H and m-CF3, the syn- and anti-rotamers of the

CL 218,872 a triazolopyridazine with a selective affinity for the benzodiazepine BZ1 receptor subtype, retards the development and expression of amygdaloid-kindled seizures: effects of flumazenil.

R K McNamara et al.

Epilepsy research, 16(1), 19-26 (1993-09-01)

To clarify the role of benzodiazepine receptors in kindling, the present experiment assessed the effects of CL 218,872 (1, 5, 10, and 20 mg/kg), a triazolopyridazine with a selective affinity for the putative benzodiazepine BZ1 receptor subtype, on the development

Differences in expression of GABAA receptor subunits, but not benzodiazepine binding, in the chick brainstem auditory system.

R L Hyson et al.

Journal of molecular neuroscience : MN, 8(3), 193-205 (1997-06-01)

Neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) of the chick brainstem auditory system show an unusual physiological response to GABA. Examination of these nuclei using in situ hybridization for GABAA receptor subunits showed a differential expression of the

Fetal, neonatal and adult expression of benzodiazepine receptor subtypes in human visual cortex.

D March et al.

European journal of pharmacology, 236(2), 333-336 (1993-05-19)

We have investigated the relative distributions of type I and type II benzodiazepine receptors in fetal, neonatal and adult human visual cortex using [3H]flunitrazepam and the triazolopyridazine, CL218872. Microdensitometry of autoradiograms show that while both benzodiazepine subtypes are found in

Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant.

D Benke et al.

The Journal of biological chemistry, 269(43), 27100-27107 (1994-10-28)

Native gamma-aminobutyric acid type A (GABAA) receptors containing different beta-subunit variants were identified immunobiochemically with antisera recognizing selectively the beta 1-, beta 2-, or beta 3-subunit. As determined by immunoprecipitation, the beta 2-subunit was present in 55-60% of GABAA receptors

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