I2892

Ifenprodil (+)-tartrate salt

• Synonyme(s) : α-(4-Hydroxyphenyl)-β-methyl-4-benzyl-1-piperidineethanol (+)-tartrate salt
• Formule linéaire : (C₂₁H₂₇NO₂)₂ · C₄H₆O₆
• Numéro CAS: 23210-58-4
• Poids moléculaire : 800.98
• Numéro CE : 245-493-5
• Numéro MDL: MFCD01529999
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278826
• Nomenclature NACRES : NA.77

Propriétés

• Température de stockage: room temp
• Niveau de qualité: 200
• Chaîne SMILES: OC(C(O)C(O)=O)C(O)=O.CC(C(O)c1ccc(O)cc1)N2CCC(CC2)Cc3ccccc3.CC(C(O)c4ccc(O)cc4)N5CCC(CC5)Cc6ccccc6
• InChI: 1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)
• Clé InChI: DMPRDSPPYMZQBT-UHFFFAOYSA-N
• Informations sur le gène: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

Description

Description générale

Ifenprodil is a phenylethanolamine, which stimulates blood circulation. It has anticonvulsant and antinociceptive properties.[1] Ifenprodil is used to treat posttraumatic stress disorder,[2] cerebrovascular diseases and peripheral arterial obliterative disease.[1] It blocks G protein-coupled inwardly-rectifying potassium channels (GIRKs) and interacts with α1 adrenergic, N-methyl-D-aspartate and serotonin receptors.[1]

Application

Ifenprodil (+)-tartrate salt has been used:

• to test the action in a KCl-induced cortical spreading depression (CSD) animal[3]
• to study its effects on electrophysiological properties and spontaneous spikes in neocortical pyramidal cells[4]
• to investigate its therapeutic effects[5]

Actions biochimiques/physiologiques

NMDA antagonist acting at the polyamine site; neuroprotective agent; α-adrenergic central and peripheral vasodilator; α₂ adrenergic receptor ligand.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves