I0406
Interleukin-6 from rat
IL-6, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Synonyme(s) :
Interleukin-6 from rat
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About This Item
Produits recommandés
Source biologique
rat
Niveau de qualité
Produit recombinant
expressed in E. coli
Pureté
>97% (SDS-PAGE)
Forme
buffered aqueous solution
Puissance
0.01-0.06 ng/mL ED50
Qualité
endotoxin tested
Poids mol.
predicted mol wt ~22 kDa
Conditionnement
pkg of 10 and 50 μg
Technique(s)
cell culture | mammalian: suitable
Impuretés
<0.01EU/mg (LAL test)
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
rat ... Il6(24498)
Actions biochimiques/physiologiques
Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
Forme physique
Supplied as a 0.2 μm filtered solution in 50 mM sodium acetate, pH 4, with BSA as a carrier protein.
Notes préparatoires
Recombinant, rat Interleukin-6 is produced from a DNA sequence encoding the mature rat IL-6 protein. The methionyl form of mature rat IL-6, a 188 amino acid protein, has a predicted molecular mass of approx. 22 kDa. Rat and mouse IL-6 share 93% amino acid sequence identity.
Remarque sur l'analyse
The biological activity is measured in a cell proliferation assay using IL-6 dependent mouse plasmacytoma cell line, T1165.85.2.1.
Produit comparable
Réf. du produit
Description
Tarif
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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