H8876

5-Hydroxyindole-3-acetic acid

≥98% (HPLC), crystalline

• Synonyme(s) : 5-HIAA
• Formule empirique (notation de Hill): C₁₀H₉NO₃
• Numéro CAS: 54-16-0
• Poids moléculaire : 191.18
• Beilstein: 168797
• Numéro CE : 200-195-4
• Numéro MDL: MFCD00005639
• Code UNSPSC : 12352106
• ID de substance PubChem : 24278130
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: 5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: crystalline
• Couleur: white to purple
• Pf: 161-164 °C (dec.) (lit.)
• Température de stockage: −20°C
• Chaîne SMILES: OC(=O)Cc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
• Clé InChI: DUUGKQCEGZLZNO-UHFFFAOYSA-N
• Informations sur le gène: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

Description

Description générale

5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway.[1] 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients.[2] Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF.[1] 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).[3]

Application

5-Hydroxyindole-3-acetic acid has been used as standard for the measurement of 5-HIAA in the brain tissue of mice using high performance liquid chromatography (HPLC).[4][5]

Actions biochimiques/physiologiques

Major serotonin metabolite.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)