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F5421

Sigma-Aldrich

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-FGFR-1

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About This Item

Numéro MDL:
MFCD00675556
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 110-120 kDa

Espèces réactives

human

Conditionnement

antibody small pack of 25 μL

Concentration

~1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using trypsin-digested human and animal tissue sections
immunoprecipitation (IP): suitable
western blot: 1:400 using an extract of FGFR-1 transfected cells

Numéro d'accès UniProt

P11362

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... FGFR1(2260)

Description générale

Fibroblast growth factor receptor 1 (FGFR-1) belongs to the family of FGFRs. At the mRNA level, FGFR-1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates.

Spécificité

Anti-FGFR-1 antibody is specific for human FGFR-1 and does not react with human FGFR-2 and FGFR-3. The immunizing peptide specifically inhibits the staining of anti-FGFR-1 antibody.
Staining of the product is specifically inhibited with the FGFR-1 immunizing peptide. No reaction with human FGFR-2 and FGFR-3 is detected.
No reaction with FGFR-2 (Bek) and FGFR-3 is detected.

Immunogène

Synthetic peptide corresponding to amino acid residues 360-373 of the extracellular region of human FGFR-1 conjugated to KLH with glutaraldehyde, and with a C-terminally added lysine.

Application

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit has been used in:
  • immunoprecipitation
  • immunofluorocytochemistry
  • immunohistochemistry
  • immunoblotting

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
Sleeman IJ, et al.
Neuropharmacology, 63 (2012)
Wei Zheng et al.
Developmental neuroscience, 26(2-4), 181-196 (2005-02-16)
Cells within the subventricular zone (SVZ) express basic Fgf (Fgf2) and Fgf receptor proteins. We show that the absence of Fgf2 gene products reduces by 50% the dividing progenitor population of the anterior SVZ (SVZa) without changing their cell cycle
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
Peters KG, et al.
Development, 114 (1992)
S F Winter et al.
Oncogene, 26(34), 4897-4907 (2007-02-14)
The expression of fibroblast growth factor receptor (FGFR)-1 correlates with angiogenesis and is associated with prostate cancer (CaP) progression. To more precisely define the molecular mechanisms whereby FGFR1 causes angiogenesis in the prostate we exploited a transgenic mouse model, JOCK-1
Frank W King et al.
Stem cells and development, 18(10), 1441-1450 (2009-03-04)
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. While subpopulations of hESCs within pluripotent cultures have been identified based on expression of specific surface antigens, their significance and fates are
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