Microsome contents of CYP1A2 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.
Définition de l'unité
P450 Activity: One unit will oxidize 1 picomole of ethoxyresorufin per minute at pH 7.4 at 28 °C. Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
This work describes the interfacing of electrowetting-on-dielectric based digital microfluidic (DMF) sample preparation devices with ambient mass spectrometry (MS) via desorption atmospheric pressure photoionization (DAPPI). The DMF droplet manipulation technique was adopted to facilitate drug distribution and metabolism assays in
Chemical research in toxicology, 33(7), 1960-1968 (2020-06-03)
Fraxinellone, a furanoid, is one of the bioactive and potentially hepatotoxic constituents from Dictamnus dasycarpus Turcz, which is extensively spread throughout Asian countries. This herb was reported to cause liver injury in clinical application. However, the mechanism behind is still
Drug metabolism and pharmacokinetics, 30(3), 247-252 (2015-05-30)
Genetic variations in cytochrome P450 1A2 (CYP1A2) are associated with interindividual variability in the metabolism and efficacy of many medications. Twenty CYP1A2 variants harboring amino acid substitutions were analyzed for functional changes in enzymatic activity. Recombinant CYP1A2 variant proteins were
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