E9750

Estrone

≥99% (HPLC), powder, estrogen receptor agonist

• Synonyme(s) : 1,3,5(10)-estratriène-3-ol-17-one, Folliculine
• Formule empirique (notation de Hill): C₁₈H₂₂O₂
• Numéro CAS: 53-16-7
• Poids moléculaire : 270.37
• Numéro Beilstein : 1915077
• Numéro CE : 200-164-5
• Numéro MDL: MFCD00003620
• Code UNSPSC : 51111800
• ID de substance PubChem : 24278427
• Nomenclature NACRES : NA.77

Propriétés

• product name: Estrone, ≥99%
• Source biologique: synthetic (organic)
• Stérilité: non-sterile
• Pureté: ≥99%
• Forme: powder
• Pf: 258-260 °C (lit.)
• Solubilité: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
• Clé InChI: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• Informations sur le gène: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , HSD17B1(3292) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Esr1(24890)

Description

Description générale

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Application

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Actions biochimiques/physiologiques

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H351,H360FD,H362
• Conseils de prudence: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Classification des risques: Carc. 2 - Lact. - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges