E8875

17β-Estradiol

≥98% (HPLC), powder, estrogenic hormone

• Synonyme(s) : 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
• Formule empirique (notation de Hill): C₁₈H₂₄O₂
• Numéro CAS: 50-28-2
• Poids moléculaire : 272.38
• Numéro Beilstein : 1914275
• Numéro CE : 200-023-8
• Numéro MDL: MFCD00003693
• Code UNSPSC : 12352104
• ID de substance PubChem : 24278426
• Nomenclature NACRES : NA.77

Propriétés

• product name: β-Estradiol, ≥98%
• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Stérilité: non-sterile
• Pureté: ≥98%
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Pf: 176-180 °C (lit.)
• Solubilité: ethanol: 50 mg/mL, clear, colorless
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• Clé InChI: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Informations sur le gène: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , GPER(2852) , SERPINA6(866) ; mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379) ; rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)

Description

Description générale

β-Estradiolis a natural steroid estrogen and a female sex hormone. It is an essential component of the female menstrual cycle and plays an important role in the growth and maintenance of the reproductive system.

Application

β-Estradiol has been used:

• for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
• as a supplement in in vitro maturation medium (IVM), which is used as a control medium
• in estrogen-induction assay

Actions biochimiques/physiologiques

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Nuclear Receptors (Steroids) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H351,H360FD,H362,H410
• Conseils de prudence: P202 - P260 - P263 - P264 - P273 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges