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E5139

Sigma-Aldrich

DL-Ethionine

≥95% (TLC)

Synonyme(s) :

DL-2-Amino-4-(ethylthio)butyric acid

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About This Item

Formule linéaire :
C2H5SCH2CH2CH(NH2)COOH
Numéro CAS:
67-21-0
Poids moléculaire :
163.24
Numéro Beilstein :
1722529
Numéro CE :
200-647-0
Numéro MDL:
MFCD00063102
Code UNSPSC :
12352209
ID de substance PubChem :
24894606
Nomenclature NACRES :
NA.26

product name

DL-Ethionine, ≥95% (TLC)

Pureté

≥95% (TLC)

Forme

powder

Couleur

white to off-white

Pf

269 °C

Application(s)

cell analysis

Température de stockage

−20°C

Chaîne SMILES 

CCSCCC(N)C(O)=O

InChI

1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)

Clé InChI

GGLZPLKKBSSKCX-UHFFFAOYSA-N

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Application


  • Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration.: This study evaluates the hepatic oxidative stress in cattle induced by ethionine administration by measuring superoxide dismutase activity. The findings suggest a significant oxidative response, highlighting the role of DL-Ethionine in studying liver oxidative mechanisms (Abd Ellah et al., 2009).

Actions biochimiques/physiologiques

DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Mami Furukawa et al.
Anticancer research, 29(10), 4047-4050 (2009-10-23)
To evaluate an involvement of LKB1 gene alteration during pancreatic carcinogenesis, mutations in the LKB1 gene in hamster pancreatic duct adenocarcinomas (PDAs) induced by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated. Female Syrian golden hamsters received 30 mg/kg of BOP followed by repeated
Muneyoshi Kanai et al.
Journal of bioscience and bioengineering, 123(1), 8-14 (2016-08-28)
Sake yeasts are ideally suited for sake making, producing higher levels of ethanol, proliferating at lower temperatures, and producing greater levels of various aromatic components and nutrients than laboratory yeasts. To elucidate the mechanism underlying S-adenosylmethionine (SAM) accumulation in sake
Yingying Liu et al.
Stem cells (Dayton, Ohio), 33(12), 3569-3580 (2015-06-03)
Upregulation of osteopontin (OPN) has been found in hepatic progenitor cells (HPCs) in several liver diseases with portal biliary proliferation. Here, we investigated the role of HPC-derived autocrine OPN in regulating HPC expansion, migration, and hepatocarcinogenesis in mice. Five-week-old, weighing
Mahmoud R Abd Ellah et al.
Veterinary journal (London, England : 1997), 182(2), 336-341 (2008-07-01)
The goal of this study was to assess if oxidative stress, as measured by alterations in the concentrations of antioxidant enzymes in the liver and erythrocytes of cattle, could be induced following dl-ethionine administration. Whole blood, serum and liver biopsy
Tirthadipa Pradhan-Sundd et al.
Gastroenterology, 155(4), 1218-1232 (2018-07-03)
Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms
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