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Merck
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C7930

Sigma-Aldrich

Anti-CD3, T Cell antibody produced in rabbit

whole antiserum

Synonyme(s) :

Anti-CD3epsilon, Anti-IMD18, Anti-T3E, Anti-TCRE

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About This Item

Numéro MDL:
MFCD00162554
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

whole antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Poids mol.

antigen 20 kDa (bovine and swine)

Contient

15 mM sodium azide

Espèces réactives

rat, canine, mouse, human, Psammomys (sand rat), sheep, feline, pig, chicken, bovine

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using enzyme pre-digested, formalin-fixed, paraffin-embedded human tonsil sections
western blot: 1:200 using mouse thymus extract

Numéro d'accès UniProt

P07766

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CD3E(916)
mouse ... Cd3e(12501)
rat ... Cd3e(315609)

Description générale

CD3 is a 20kDa glycoprotein expressed on surface of all human T lymphocytes. CD3 molecule is encoded by the gene mapped to human chromosome 11q23.3. The CD3 antigen is expressed during thymopoiesis. It is also present in the majority of T-CLL and T-lymphomas and in approximately 70% of T-ALL.

Spécificité

The antibody reacts with the proline-rich peptide sequence comprising 13 amino acids in the cytoplasmic domain of the CD3-ε chain. It detects normal, reactive and most neoplastic human T cells in routinely processed enzyme pre-digested, formalin-fixed, paraffin-embedded tissue sections. The antibody also reacts with human tissues fixed with Bouin′s solution and embedded in paraffin. Frozen sections and smears are also suitable for staining with this antibody. The antibody reacts with T cell areas in lymphoid tissues derived from various species.

Immunogène

synthetic human CD3 peptide (residues 156-168 of the CD3-ε chain) coupled to porcine thyroglobulin. Coupling was performed by a modification of the reported method.

Application

Anti-CD3, T Cell antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence staining
  • immunohistochemistry
  • immunohistochemical analysis

Actions biochimiques/physiologiques

CD3 is a human cell surface glycoprotein complex involved in signal transduction following binding of antigen receptor.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Fabian P S Yu et al.
Scientific reports, 8(1), 1808-1808 (2018-01-31)
Farber Disease (FD) is an ultra-rare Lysosomal Storage Disorder caused by deficient acid ceramidase (ACDase) activity. Patients with ACDase deficiency manifest a spectrum of symptoms including formation of nodules, painful joints, and a hoarse voice. Classic FD patients will develop
Nadir Kadri et al.
Journal of immunology (Baltimore, Md. : 1950), 188(7), 3138-3149 (2012-03-01)
Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have the ability to regulate immunity, including autoimmunity. We previously demonstrated that CD1d-restricted type II NKT cells, which
Most Jacobsen syndrome deletion breakpoints occur distal to FRA11B.
Michaelis RC, et al.
American Journal of Medical Genetics (1998)
Chuanhai Cao et al.
Neurobiology of disease, 34(1), 63-70 (2009-01-27)
We have found that a small number of purified Th2-biased Abeta-specific T cells are sufficient to provide profound cognitive and pathological benefits in an APP+PS1 mouse model for Alzheimer's disease. Six weeks after receiving T cell infusions, cognitively-impaired mice performed
Precocious gut maturation and immune cell expansion by single dose feeding the lectin phytohaemagglutinin to suckling rats
Prykhodko O, et al.
The British Journal of Nutrition, 101(5), 735-742 (2008)
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