B4311

BF-170 hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : 2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride
• Formule empirique (notation de Hill): C₁₅H₁₂N₂ · HCl
• Numéro CAS: 22191-97-5
• Poids moléculaire : 256.73
• Numéro MDL: MFCD08705340
• Code UNSPSC : 12352200
• ID de substance PubChem : 24891766
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated; protect from light; under inert gas
• Couleur: orange
• Solubilité: H₂O: 10 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2
• InChI: 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
• Clé InChI: UYYPMQOFLJHJAW-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC₅₀ = 221 nM vs. EC₅₀ = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

Attention

Product is air sensitive, store under inert gas.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H318,H335
• Conseils de prudence: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves