A7085

Acétaminophène

BioXtra, ≥99.0%

• Synonyme(s) : 4′-Hydroxyacétanilide, 4-Acétaminophène, N-(4-Hydroxyphényl)acétamide, N-Acétyl-4-aminophénol, APAP, Paracétamol
• Formule linéaire : CH₃CONHC₆H₄OH
• Numéro CAS: 103-90-2
• Poids moléculaire : 151.16
• Beilstein: 2208089
• Numéro CE : 203-157-5
• Numéro MDL: MFCD00002328
• Code UNSPSC : 12352111
• ID de substance PubChem : 24891173
• Nomenclature NACRES : NA.25
• Forme: powder
• Essai: ≥99.0%

Propriétés

• Gamme de produits: BioXtra
• Niveau de qualité: 200
• Essai: ≥99.0%
• Forme: powder
• Impuretés: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• Résidus de calcination: ≤0.1%
• Pf: 168-172 °C (lit.)
• Solubilité: ethanol: 0.5 M, clear, colorless
• Traces d'anions: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• Traces de cations: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• Chaîne SMILES: CC(=O)Nc1ccc(O)cc1
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
• Clé InChI: RZVAJINKPMORJF-UHFFFAOYSA-N
• Informations sur le gène: human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

Description

Description générale

Acetaminophen or paracetamol is an analgesic and antipyretic.[1] It is however a weak non opioid analgesic.[2]

Application

Acetaminophen has been used:

• as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels[3]
• to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons[4]
• as a hepatocellular injury inducing agent in mice[5]

Analgésique.

Actions biochimiques/physiologiques

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor.[1] Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities.[6] It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.[2]

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 364.3 °F - Pensky-Martens closed cup
• Point d'éclair (°C): 184.6 °C - Pensky-Martens closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves