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A5486

Sigma-Aldrich

Azoxyméthane

13.4 M, ≥98%

Synonyme(s) :

AOM

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25 MG
455.00 CHF
100 MG
1 480.00 CHF

455.00 CHF

Date d'expédition estimée le28 mai 2025

Devis pour commande en gros
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25 MG
455.00 CHF
100 MG
1 480.00 CHF

About This Item

Formule linéaire :
CH3N=N(→O)CH3
Numéro CAS:
25843-45-2
Poids moléculaire :
74.08
Numéro MDL:
MFCD00126912
Code UNSPSC :
12352124
ID de substance PubChem :
329770827
Nomenclature NACRES :
NA.25

455.00 CHF

Date d'expédition estimée le28 mai 2025

Devis pour commande en gros

Essai

≥98%

Forme

liquid

Composition

methylene chloride, ≤1%

Conditions de stockage

(Keep container tightly closed in a dry and well-ventilated place.)

Concentration

13.4 M

Couleur

colorless

pb

97-99 °C (lit.)

Densité

0.991 g/mL at 25 °C (lit.)

Application(s)

genomic analysis

Température de stockage

−20°C

Chaîne SMILES 

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

Clé InChI

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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Description générale

L'azoxyméthane (AOM) est un produit chimique de laboratoire puissant servant à étudier l'initiation, la progression et la prévention du cancer, en particulier dans le côlon. C'est à la fois un agent cancérigène qui déclenche la formation de tumeurs, et un agent mutagène qui provoque des altérations spécifiques dans l'ADN.

Application

L′azoxyméthane (AOM), agent provoquant des mutations de l′ADN, peut être utilisé avec le sulfate de dextrane sodique (DSS) pour créer des modèles du cancer dans des animaux de laboratoire en vue d′étudier les mécanismes de progression et de chimioprévention du cancer.

Actions biochimiques/physiologiques

Cancérigène qui induit la formation d′adduits O6-méthylguanine dans l′ADN qui mènent à des transitions G→A. Il induit une tumorigenèse dans le côlon d′animaux de laboratoire et est utilisé pour étudier le mécanisme de progression tumorale et de chimioprévention.

Caractéristiques et avantages

Produit polyvalent et pouvant s'adapter à un large éventail d'applications de laboratoire et de recherche.

Autres remarques

Il est essentiel de déterminer la concentration correcte d′azoxyméthane dans le schéma expérimental pour éviter la mort prématurée des animaux de laboratoire.
Pour de plus amples informations sur notre gamme de Produits biochimiques, merci de compléter ce formulaire.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

06693

Timestrip Plus™ -20 °C

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H226,H300,H315,H319,H350

Classification des risques

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

75.2 °F

Point d'éclair (°C)

24 °C

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
0000431531
0000431531
0000346492
0000346490
0000335813

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Eva Pastille et al.
PLoS pathogens, 13(9), e1006649-e1006649 (2017-09-25)
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules
Sonia Leon-Cabrera et al.
Cancers, 10(9) (2018-09-22)
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor⁻stroma interactions, and
Carlotta Tacconi et al.
Cancer research, 79(16), 4196-4210 (2019-06-27)
Colorectal cancer is a major cause of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LV) and tumor-associated macrophages (TAM). The VEGFC/VEGFR3 pathway is regarded as the principal inducer of lymphangiogenesis and it contributes
Anne Chastre et al.
PloS one, 7(11), e49670-e49670 (2012-11-21)
Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results from massive loss of hepatocytes and may lead to hepatic encephalopathy (HE), a serious neuropsychiatric complication. Although increased expression of tumor necrosis factor-alpha
Qifan Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4779-4782 (2014-10-17)
Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense
Afficher tous les articles scientifiques apparentés

Questions

1–10 of 11 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 answer

    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

      Helpful?

  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 answer

    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

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  5. Is Axozymethane volatile?

    1 answer

    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

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  6. How does azoxymethane act to cause cancers?

    1 answer

    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

      Helpful?

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 answer

    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

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  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  9. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  10. What solvents can be used to dissolve Azoxymethane?

    1 answer

    1. Azoxymethane is soluble in water, ether, ethanol, and chloroform. The reported solubility in chlorform is 200 mg/mL, and in water is 100 mg/mL.

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1–10 of 11 Questions  

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