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A2853

Sigma-Aldrich

Azoxyméthane

Practical grade, 13.4 M, ≥90% (GC)

Synonyme(s) :

AOM

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About This Item

Formule linéaire :
CH3N=N(→O)CH3
Numéro CAS:
25843-45-2
Poids moléculaire :
74.08
Numéro MDL:
MFCD00126912
Code UNSPSC :
12352200
ID de substance PubChem :
24890698

Pureté

≥90% (GC)

Qualité

Practical grade

Contient

≤15% ethanol and acetic acid (Packaged based on azoxymethane.)

Composition

methylene chloride, ≤5% (solvent)

Concentration

13.4 M

Point d'ébullition

97-99 °C (lit.)

Densité

0.991 g/mL at 25 °C (lit.)

Température de stockage

−20°C

Chaîne SMILES 

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

Clé InChI

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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Actions biochimiques/physiologiques

Cancérigène qui induit la formation d′adduits O6-méthylguanine dans l′ADN qui mènent à des transitions G→A. Il induit une tumorigenèse dans le côlon d′animaux de laboratoire et est utilisé pour étudier le mécanisme de progression tumorale et de chimioprévention.

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

75.2 °F

Point d'éclair (°C)

24 °C

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What solvents can be used to dissolve Azoxymethane?

    Azoxymethane is soluble in water, ether, ethanol, and chloroform. The reported solubility in chlorform is 200 mg/mL, and in water is 100 mg/mL.

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

  8. How does azoxymethane act to cause cancers?

    Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Anne Chastre et al.
PloS one, 7(11), e49670-e49670 (2012-11-21)
Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results from massive loss of hepatocytes and may lead to hepatic encephalopathy (HE), a serious neuropsychiatric complication. Although increased expression of tumor necrosis factor-alpha
Qifan Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4779-4782 (2014-10-17)
Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense
Soumen K Manna et al.
Gastroenterology, 146(5), 1313-1324 (2014-01-21)
There are no robust noninvasive methods for colorectal cancer screening and diagnosis. Metabolomic and gene expression analyses of urine and tissue samples from mice and humans were used to identify markers of colorectal carcinogenesis. Mass spectrometry-based metabolomic analysis of urine
Michael D Burkitt et al.
The Journal of pathology, 236(3), 326-336 (2015-03-03)
NF-κB signalling is an important factor in the development of inflammation-associated cancers. Mouse models of Helicobacter-induced gastric cancer and colitis-associated colorectal cancer have demonstrated that classical NF-κB signalling is an important regulator of these processes. In the stomach, it has
Vasiliki Koliaraki et al.
The Journal of clinical investigation, 122(11), 4231-4242 (2012-10-16)
The tumor microenvironment plays a significant role in colitis-associated cancer (CAC). Intestinal myofibroblasts (IMFs) are cells in the intestinal lamina propria secreting factors that are known to modulate carcinogenesis; however, the physiological role of IMFs and signaling pathways influencing CAC
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