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F0005000

Famotidine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Famotidine, N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

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About This Item

Formule empirique (notation de Hill) :
C8H15N7O2S3
Numéro CAS:
Poids moléculaire :
337.45
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
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Source biologique

synthetic

Qualité

pharmaceutical primary standard

Agence

EP Reference Standard

Famille d'API

famotidine

Forme

solid

Conditionnement

pkg of 110 mg

Fabricant/nom de marque

EDQM

Conditions de stockage

protect from light

Application(s)

pharmaceutical (small molecule)

Format

neat

Conditions d'expédition

ambient

Température de stockage

2-8°C

Chaîne SMILES 

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

Clé InChI

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Informations sur le gène

human ... HRH2(3274)

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Description générale

Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.[1][2][3]

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

H2 histamine receptor antagonist; anti-ulcer agent

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Famotidine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 29(1-2), 2609-2610 (2017)
Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones
Campbell AN and Sherma J
Journal of Liquid Chromatography and Related Technologies, 26(16), 2719-2727 (2003)
Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry
Kelani KM, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)
C W Howden et al.
Clinical therapeutics, 18(1), 36-54 (1996-01-01)
Famotidine is a specific, long-acting histamine2-receptor antagonist. It is indicated for the treatment of duodenal ulcer, gastric ulcer, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. Since its introduction for the treatment of acid-related disorders in 1985, an estimated 18.8 million patients
H Echizen et al.
Clinical pharmacokinetics, 21(3), 178-194 (1991-09-01)
Famotidine is a potent histamine H2-receptor antagonist widely used in the treatment and prevention of peptic ulcer disease. After intravenous administration the plasma famotidine concentration-time profile exhibits a biexponential decay, with a distribution half-life of about 0.18 to 0.5h and

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