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C1200000

Chloramphénicol

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

D-(−)-thréo-2,2-dichloro-N-[β-hydroxy-α-(hydroxyméthyl)-β-(4-nitrophényl)éthyl]acétamide, D-(−)-threo-2-dichloroacétamido-1-(4-nitrophényl)-1,3-propanediol, D-threo-2,2-dichloro-N-[β-hydroxy-α-(hydroxyméthyl)-4-nitrophenéthyl]acétamide, Chloromycétine

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About This Item

Formule linéaire :
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Numéro CAS:
56-75-7
Poids moléculaire :
323.13
Numéro Beilstein :
2225532
Numéro MDL:
MFCD00078159
Code UNSPSC :
41116107
ID de substance PubChem :
329774875
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

chloramphenicol

Fabricant/nom de marque

EDQM

Pf

149-153 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

Clé InChI

WIIZWVCIJKGZOK-RKDXNWHRSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chloramphenicol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Mode d'action : Le chloramphénicol inhibe la synthèse protéique bactérienne en bloquant l'étape de la peptidyl transférase en se fixant à la sous-unité ribosomale 50S et en empêchant la fixation de l'aminoacyl-ARNt au ribosome. Il inhibe également la synthèse protéique dans les mitochondries et les chloroplastes et la formation des ribosomes par les (p)ppGpp, ralentissant ainsi la transcription de l'ARNr.

Mode de résistance : La chloramphénicol acétyltransférase acétyle, et donc, inactive le produit.

Spectre antimicrobien : Il s'agit d'un antibiotique à large spectre actif sur les bactéries à Gram positif et les bactéries à Gram négatif principalement destiné à un usage ophtalmologique et vétérinaire.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

C1400000

Chloramphenicol palmitate isomer, European Pharmacopoeia (EP) Reference Standard

C1300000

Chloramphenicol dipalmitate, European Pharmacopoeia (EP) Reference Standard

C1425000

Chloramphenicol sodium succinate, European Pharmacopoeia (EP) Reference Standard

C1350000

Chloramphenicol disodium disuccinate, European Pharmacopoeia (EP) Reference Standard

1107004

Chloramphénicol, United States Pharmacopeia (USP) Reference Standard

1107300

Chloramphenicol palmitate, United States Pharmacopeia (USP) Reference Standard

1107401

Chloramphenicol palmitate, United States Pharmacopeia (USP) Reference Standard

1107503

Chloramphenicol palmitate, United States Pharmacopeia (USP) Reference Standard

BP854

Chloramphénicol, British Pharmacopoeia (BP) Reference Standard

BP1061

Chloramphenicol sodium succinate, British Pharmacopoeia (BP) Reference Standard

BP417

2-Amino-1-(4-nitrophenyl)propane-1,3-diol, British Pharmacopoeia (BP) Reference Standard

Pictogrammes

Health hazardCorrosion
GHS08,GHS05

Mention d'avertissement

Danger

Mentions de danger

H318,H351,H361fd

Classification des risques

Carc. 2 - Eye Dam. 1 - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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