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BCR134

Benzo[c]phenanthrene

BCR®, certified reference material

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About This Item

Formule empirique (notation de Hill):
C18H12
Numéro CAS:
195-19-7
Poids moléculaire :
228.29
Numéro Beilstein :
1909296
Numéro CE :
205-896-9
Numéro MDL:
MFCD00019126
Code UNSPSC :
41116107
ID de substance PubChem :
329774224
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Agence

BCR®

Fabricant/nom de marque

JRC

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

c1ccc2c(c1)ccc3ccc4ccccc4c23

InChI

1S/C18H12/c1-3-7-16-13(5-1)9-11-15-12-10-14-6-2-4-8-17(14)18(15)16/h1-12H

Clé InChI

TUAHORSUHVUKBD-UHFFFAOYSA-N

Catégories apparentées

Remarque sur l'analyse

For more information please see:
BCR134

Informations légales

BCR is a registered trademark of European Commission

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Lot/Batch Number

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Jianxin Wu et al.
Nucleic acids research, 31(22), 6428-6434 (2003-11-07)
Benzo[c]phenanthrene dihydrodiol epoxide (B[c] PhDE) is well known as an important environmental chemical carcinogen that preferentially modifies DNA in adenine residues. However, the molecular mechanism by which B[c]PhDE induces tumorigenesis is not fully understood. In this report, we demonstrate that
S R Vepachedu et al.
Chemical research in toxicology, 13(9), 883-890 (2000-09-20)
Distributions of adducts formed from each of the four optically active isomers of 3,4-dihydroxy-1,2-epoxy-1,2,3, 4-tetrahydrobenzo[c]phenanthrene and of 7,8-dihydroxy-9,10-epoxy-7,8, 9,10- tetrahydrobenzo[a]pyrene (BcPh and BaP diol epoxides) on reaction with an equimolar mixture of deoxyadenosine and deoxyguanosine 5'-monophosphates were compared with the
Hui-Fang Chang et al.
Chemical research in toxicology, 15(2), 198-208 (2002-02-19)
This paper reports structural characterization of the adducts and tetraols formed from syn-benzo[ghi]fluoranthene-3,4-dihydrodiol-5,5a-epoxide (syn-B[ghi]FDE, 3) and comparative DNA-binding and mutagenicity studies involving 3, anti-B[ghi]FDE (2), and anti-benzo[c]phenanthrene-11,12-dihydrodiol-13,14-epoxide (anti-BcPDE, 5). The structures of nine DNA adducts and two racemic tetraols derived
M Baum et al.
Chemical research in toxicology, 14(6), 686-693 (2001-06-21)
The environmentally occurring polycyclic aromatic hydrocarbon (PAH) benzo[c]phenanthrene (B[c]PH) is a weak carcinogen in rodents. In contrast, the dihydrodiol-epoxides of B[c]PH are among the most carcinogenic PAH metabolites tested so far. In rodents, B[c]PH is predominantly metabolized to B[c]PH-5,6-dihydrodiol (B[c]PH-5,6-DH)
H J Einolf et al.
Chemical research in toxicology, 10(5), 609-617 (1997-05-01)
The environmental contaminant benzo[c]phenanthrene (B[c]Ph) has weak carcinogenic activity in rodent bioassays; however, the fjord region diol epoxides of B[c]Ph, B[c]Ph-3,4-diol 1,2-epoxides (B[c]PhDE), are potent carcinogens. To determine the role of cytochrome P450 isozymes in the activation of B[c]Ph in
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