Chemical research in toxicology, 12(1), 60-67 (1999-01-20)
The formation of DNA adducts in mouse epidermis has been examined following topical application of dibenz[a,j]anthracene (DB[a,j]A) and its metabolites, i.e., DB[a,j]A-3,4-diol, DB[a,j]A-3,4-10, 11-bis-diol, DB[a,j]A-3,4-8,9-bis-diol, 10-OH-DB[a,j]A-3,4-diol, or 11-OH-DB[a,j]A-3,4-diol, using a 32P-postlabeling assay. At initiating doses (400-1600 nmol), DB[a,j]A produced at
Chemical research in toxicology, 4(1), 115-122 (1991-01-01)
Identification of various deoxyribonucleoside adducts formed in primary cultures of mouse keratinocytes exposed to dibenz[a,j]anthracene (DB[a,j]A) is presented. A preliminary analysis of the DNA adducts formed from 7-methyldibenz[a,j]anthracene (7MeDB[a,j]A) also is presented. Cultures of keratinocytes obtained from dorsal skins of
Chemical research in toxicology, 8(2), 292-301 (1995-03-01)
The formation of deoxyribonucleoside adducts in mouse epidermis has been examined following topical application of [3H]dibenz[a,j]anthracene (DB[a,j]A) or by 32P-postlabeling following topical application of unlabeled DB[a,j]A, DB[a,j]A trans-3,4-diol or the anti- or syn-3,4-diol 1,2-epoxides. A single topical application of [3H]DB[a,j]A
Dibenz[a,j]anthracene.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 32, 309-313 (1983-12-01)
Chemical research in toxicology, 5(4), 532-540 (1992-07-01)
The identification of several metabolites formed from dibenz[aj]anthracene (DB[aj]A) and 7-methyldibenz[aj]anthracene (7MeDB[aj]A) in primary cultures of mouse keratinocytes is presented. The metabolites were analyzed by coelution with known synthetic standards using high-pressure liquid chromatography. The metabolite identifications were further facilitated
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