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B2635

Supelco

Busulfan

analytical standard, for drug analysis

Synonyme(s) :

1,4-Butanediol dimethanesulfonate

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10 G
40.60 CHF
25 G
82.30 CHF

40.60 CHF


Date d'expédition estimée le23 mai 2025


Devis pour commande en gros

Sélectionner une taille de conditionnement

Changer de vue
10 G
40.60 CHF
25 G
82.30 CHF

About This Item

Formule linéaire :
CH3SO2O(CH2)4OSO2CH3
Numéro CAS:
Poids moléculaire :
246.30
Beilstein:
1791786
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

40.60 CHF


Date d'expédition estimée le23 mai 2025


Devis pour commande en gros

Qualité

analytical standard, for drug analysis

Niveau de qualité

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

114-117 °C (lit.)

Application(s)

forensics and toxicology
veterinary

Format

neat

Chaîne SMILES 

CS(=O)(=O)OCCCCOS(C)(=O)=O

InChI

1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

Clé InChI

COVZYZSDYWQREU-UHFFFAOYSA-N

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Description générale

Busulfan is a bifunctional alkylating agent[1], which may find application in the treatment of chronic granulocytic leukemia.[1]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Skull and crossbonesHealth hazard

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

Lot/Batch Number

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Les clients ont également consulté

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Arnon Nagler et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(28), 3549-3556 (2013-08-28)
Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are currently the most common myeloablative regimens used in allogeneic stem-cell transplantation (alloSCT) in adults with acute myelogenous leukemia (AML). Intravenous (IV) Bu has more predictable bioavailability and a
Yan Zhao et al.
Stem cell research & therapy, 11(1), 466-466 (2020-11-06)
Premature ovarian insufficiency (POI) is an ovarian dysfunction that seriously affects a woman's physiological health and reproduction. Mesenchymal stem cell (MSC) transplantation offers a promising treatment option for ovarian restoration in rodent POI models. However, the efficacy and mechanism of
Edward A Copelan et al.
Blood, 122(24), 3863-3870 (2013-09-26)
Cyclophosphamide combined with total body irradiation (Cy/TBI) or busulfan (BuCy) are the most widely used myeloablative conditioning regimens for allotransplants. Recent data regarding their comparative effectiveness are lacking. We analyzed data from the Center for International Blood and Marrow Transplant
Christopher Bredeson et al.
Blood, 122(24), 3871-3878 (2013-10-02)
We conducted a prospective cohort study testing the noninferiority of survival of ablative intravenous busulfan (IV-BU) vs ablative total body irradiation (TBI)-based regimens in myeloid malignancies. A total of 1483 patients undergoing transplantation for myeloid malignancies (IV-BU, N = 1025;

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. SDSに保管温度や溶解条件等が見当たらないので教えていただけますでしょうか。また、現在HPLCの標準物質として使用しており、MeOHに溶解後、乾固凍結、使用時に再溶解しています。溶解後の保存についても最適な方法(乾固の有無・温度・期間)を教えてください。

    1 answer
    1. The neat product is to be stored at room temperature. Busulfan is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of busulfan in these solvents is approximately 16.7 mg/ml. No solution stability studies are performed for this compound but the literature recommends using the prepared solution within 24 hours.

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