33454

Potassium clavulanate

VETRANAL^®, analytical standard

• Synonyme(s) : Clavulanate potassium
• Formule empirique (notation de Hill): C₈H₈NO₅K
• Numéro CAS: 61177-45-5
• Poids moléculaire : 237.25
• Numéro CE : 262-640-9
• Numéro MDL: MFCD01710901
• Code UNSPSC : 41116107
• ID de substance PubChem : 329754553
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 200
• Gamme de produits: VETRANAL^®
• Durée de conservation: limited shelf life, expiry date on the label
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Application(s): agriculture; clinical; environmental; forensics and toxicology; pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: [K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO
• InChI: 1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
• Clé InChI: ABVRVIZBZKUTMK-JSYANWSFSA-M

Description

Description générale

Potassium clavulanate is an oxapenam derivative and belongs to the group of β-lactamase inhibitors. It is used in combination with the penicillin group of antibiotics to give them resistance to β-lactamase.

Application

The analytical standard can be used as follows:

• Simultaneous analysis of amoxicillin and clavulanate potassium in pharmaceutical formulations by capillary electrophoresis (CE) combined with capacitively coupled contactless conductivity detection (C⁴D)
• Development of a stability-indicating high-performance liquid chromatographic (HPLC) method combined with mass spectrometry (MS) to measure amoxicillin, clavulanate potassium, and their impurities in their combined dosage forms
• Residue analysis of potassium clavulanate and amoxicillin trihydrate by a UV spectrophotometric method in their bulk, combined tablet formulations, and human urine samples
• HPLC method-based determination of meropenem and potassium clavulanate in the presence of their degradation impurities in intravenous solutions in combination with a diode array detector (DAD)
• Determination of amoxicillin and clavulanic acid by capillary zone electrophoresis (CZE) in their combined commercial formulations

Actions biochimiques/physiologiques

β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Autres remarques

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informations légales

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H228,H252,H317,H334
• Conseils de prudence: P210 - P235 - P240 - P241 - P280 - P302 + P352
• Classification des risques: Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
• Risques supp: EUH044
• Code de la classe de stockage: 4.2 - Pyrophoric and self-heating hazardous materials
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)