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Posaconazole

VETRANAL®, analytical standard

Synonyme(s) :

4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

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About This Item

Formule empirique (notation de Hill):
C37H42F2N8O4
Numéro CAS:
171228-49-2
Poids moléculaire :
700.78
Numéro MDL:
MFCD00941162
Code UNSPSC :
41116107
ID de substance PubChem :
329753992
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Gamme de produits

VETRANAL®

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

clinical testing

Format

neat

Chaîne SMILES 

CC[C@@H]([C@H](C)O)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OC[C@@H]5CO[C@@](C5)(Cn6cncn6)c7ccc(F)cc7F)cc4

InChI

1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1

Clé InChI

RAGOYPUPXAKGKH-XAKZXMRKSA-N

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Catégories apparentées

Description générale

Posaconazole is an azole antifungal drug used mostly against zygomycetes.

Application

Posaconazole may have been used as reference standard in HPLC analysis for quantification of posaconazole from human plasma.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informations légales

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
BCCK0662
BCCH9785
BCCC8920
BCCB7317
BCBT7167

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Posaconazole as salvage therapy for zygomycosis.
Greenberg, R. N., et al.
Antimicrobial Agents and Chemotherapy, 50.1, 126-133 (2006)
Soraya Eugenia Morales-López et al.
Mycopathologia, 181(11-12), 871-878 (2016-09-30)
The presence of the cryptic species belonging to the Candida glabrata complex has not been studied in Argentina. We analyzed a collection of 117 clinical isolates of C. glabrata complex belonging to a National Culture Collection of Instituto Nacional de
Shuwen Deng et al.
Emerging microbes & infections, 6(12), e109-e109 (2017-12-07)
This study investigated the triazole phenotype and genotypic of clinical Aspergillus fumigatus isolates from China. We determined the triazole susceptibility profiles of 159 A. fumigatus isolates collected between 2011 and 2015 from four different areas in China tested against 10
Dorival Martins et al.
Scientific reports, 9(1), 9185-9185 (2019-06-27)
Fungi respond to antifungal drugs by increasing their antioxidant stress response. How this impacts antifungal efficacy remains controversial and not well understood. Here we examine the role of catalase activity in the resistance of Saccharomyces cerevisiae to the common antifungals
Shu-Ying Yu et al.
Infection and drug resistance, 11, 1537-1547 (2018-10-06)
Trichosporon dohaense is a rare fungal species that has not been described in human invasive infections. In this study, we investigated two T. dohaense isolates from patients with invasive infections in two hospitals in China, as part of the China
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