14400

Biotine

≥99.0% (T)

• Synonyme(s) : D-Biotine, Bios II, Coenzyme R, Vitamine B7, Vitamine H
• Formule empirique (notation de Hill) : C₁₀H₁₆N₂O₃S
• Numéro CAS: 58-85-5
• Poids moléculaire : 244.31
• Beilstein: 86838
• Numéro CE : 200-399-3
• Numéro MDL: MFCD00005541
• Code UNSPSC : 12352201
• eCl@ss : 34058011
• ID de substance PubChem : 329750287
• Nomenclature NACRES : NA.21

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥99.0% (T)
• Forme: powder
• Activité optique: [α]20/D +91±2°, c = 1% in 0.1 M NaOH
• Résidus de calcination: ≤0.1% (as SO₄)
• Perte: ≤0.5% loss on drying
• Couleur: colorless to white
• Pf: 229-234 °C; 231-233 °C (lit.)
• Solubilité: alcohol: soluble 80mg/100 ml at 25 °C; water: soluble 22mg/100 ml at 25 °C; 0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless; H₂O: very soluble; organic solvents: insoluble
• Traces de cations: Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤10 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤500 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Application(s): detection
• Chaîne SMILES: [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
• InChI: 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
• Clé InChI: YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Description

Description générale

Biotin is readily available in several foods, like whole grains, nuts, legumes, unpolished rice and egg yolk. The normal gut flora also produces this vitamin.[1]

Application

Biotin has been used for testing the functionality of the Avidin-displaying phages.[2] The product has also been used for labeling the swine anti-rabbit IgG antibody and peroxidase.[3]

Actions biochimiques/physiologiques

Biotin acts as an important cofactor for carboxylase enzymes in various metabolic pathways. Biotin favors keratin synthesis and hence is used as a supplement for hair and nail growth. Deficiency of biotin shows several symptoms such as alopecia, conjunctivitis, seborrheic dermatitis, depression, lethargy, hypotonia and seizures.[1]

Biotin also referred to as vitamin H or vitamin B7 is a water-soluble B-vitamin that induces two to three fold increase in guanylate cyclase activity in rat liver, kidney, colon, cerebellum, and heart.[4] It also stimulates the sperm motility and prolongs the survival of cryopreserved human spermatozoa.[5]

Autres remarques

Reviews[6][7]; Avidin-Biotin technology;

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)