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03930590

Protocatechuic acid

primary reference standard

Synonyme(s) :

3,4-Dihydroxybenzoic acid, Protocatechuic acid

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About This Item

Formule linéaire :
(HO)2C6H3CO2H
Numéro CAS:
99-50-3
Poids moléculaire :
154.12
Beilstein:
1448841
Numéro CE :
202-760-0
Numéro MDL:
MFCD00002509
Code UNSPSC :
85151701
ID de substance PubChem :
329747840
Nomenclature NACRES :
NA.24

187.00 CHF

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Qualité

primary reference standard

Durée de conservation

limited shelf life, expiry date on the label

Fabricant/nom de marque

HWI

Pf

197-200 °C (dec.) (lit.)

Application(s)

food and beverages

Chaîne SMILES 

OC(=O)c1ccc(O)c(O)c1

InChI

1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)

Clé InChI

YQUVCSBJEUQKSH-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Protocatechuic acid belongs to the class of polyphenolic compounds, which can be generally isolated from the dried flower of roselle.[1][2] It can serve as a potential candidate possessing anticancer property, which can be involved in suppressing the growth of human promyelocytic leukemia HL-60 cells.[1]

Application

Reference Standard in the analysis of herbal medicinal products

Actions biochimiques/physiologiques

Chemopreventive in several animal models of carcinogenesis. Blocks cell proliferation in the post-initiation phase.

Autres remarques

This compound is commonly found in plants of the genus: allium carum cinnamomum curcuma ginkgo humulus melissa pimpinella thymus

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
HWI03166-1
HWI03166
HWI02119-2
HWI02119-1
HWI02119

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Sigma-Aldrich

D7927

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Syringic acid ≥95% (HPLC)

Sigma-Aldrich

S6881

Syringic acid

Caffeic acid ≥98.0% (HPLC)

Sigma-Aldrich

C0625

Caffeic acid

Syringic acid analytical standard

Supelco

63627

Syringic acid

T H Tseng et al.
Biochemical pharmacology, 60(3), 307-315 (2000-06-17)
Hibiscus protocatechuic acid (PCA), a phenolic compound isolated from the dried flower of Hibiscus sabdariffa L. (Malvaceae), demonstrated antioxidant and antitumor promotion effects in our previous study. In the present study, Hibiscus PCA was found to inhibit the survival of
In vivo protective effect of protocatechuic acid on tert-butyl hydroperoxide-induced rat hepatotoxicity
Liu C-L, et al.
Food And Chemical Toxicology, 40, 635-641 (2002)
Saravanan Palani et al.
eLife, 10 (2021-07-17)
Actin filaments are central to numerous biological processes in all domains of life. Driven by the interplay with molecular motors, actin binding and actin modulating proteins, the actin cytoskeleton exhibits a variety of geometries. This includes structures with a curved
Paola Vitaglione et al.
The Journal of nutrition, 137(9), 2043-2048 (2007-08-22)
The metabolic fate of dietary anthocyanins (ACN) has not been fully clarified in humans. In all previous studies, the proportion of total ACN absorbed and excreted in urine was <1% intake. This study aimed to elucidate the human metabolism of
Qing-Han Gao et al.
Journal of agricultural and food chemistry, 60(38), 9642-9648 (2012-09-11)
This study investigated the changes in sugars, organic acids, α-tocopherol, β-carotene, phenolic profiles, total phenolic content (TPC), and antioxidant capacity of jujube fruits after four drying treatments (sun-, oven-, microwave- and freeze-drying). Sugar, organic acid, phenolic compounds, α-tocopherol, and β-carotene
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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