AB17003
Anti-Bim Antibody, internal epitope, pan-Bim isoforms
Chemicon®, from rabbit
Synonyme(s) :
BOD
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100 μG
449.00 CHF
449.00 CHF
Date d'expédition estimée le30 mai 2025
Un anticorps recombinant, sans conservateur, est disponible pour votre cible. Essayez ZRB1375
Devis pour commande en gros
Sélectionner une taille de conditionnement
Changer de vue
100 μG
449.00 CHF
About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
449.00 CHF
Date d'expédition estimée le30 mai 2025
Un anticorps recombinant, sans conservateur, est disponible pour votre cible. Essayez ZRB1375
Devis pour commande en gros
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
mouse, human, rat
Fabricant/nom de marque
Chemicon®
Technique(s)
western blot: suitable
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TMBIM4(51643)
Spécificité
Recognizes pan-Bim isoforms.
Immunogène
Epitope: internal epitope, pan-Bim isoforms
Synthetic peptide corresponding to amino acids 22-40 of human origin (O′Conneor et al. 1998). The sequence is identical to that of mouse and is different by one amino acid from that of rat.
Application
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
BCL2 & Inhibition
This Anti-Bim Antibody, internal epitope, pan-Bim isoforms is validated for use in WB for the detection of Bim.
Western blot: 1:1000-1:2000
Human K562 cell lysate can be used as a positive control and a 23 kDa band can be detected.
Optimal working dilutions must be determined by end user.
Human K562 cell lysate can be used as a positive control and a 23 kDa band can be detected.
Optimal working dilutions must be determined by end user.
Description de la cible
23 kDa
Forme physique
Format: Purified
ImmunoAffinity Purified
Immunoaffinity Purified immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Stockage et stabilité
The undiluted antibody solution is stable for approximately 6 months when stored 2–8°C.
Remarque sur l'analyse
Control
Skin/Skin Tumor
Skin/Skin Tumor
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Julia P Huang et al.
Oncology letters, 14(5), 5735-5742 (2017-11-09)
Enhancer of zeste homolog 2 (EZH2), a subunit of polycomb repressive complex 2, is a histone methyl-transferase and is considered to work cooperatively with histone deacetylases (HDACs) in the same protein complex to mediate gene transcription repression by increasing histone
A Malyukova et al.
Leukemia, 27(5), 1053-1062 (2012-12-12)
Loss of function mutation in FBXW7, an E3 ubiquitin ligase, is associated with good prognosis and early glucocorticoid treatment response in childhood T-cell acute lymphoblastic leukemia (T-ALL) by unknown mechanisms. Here, we show that FBXW7 targets the glucocorticoid receptor α
Shannon M Matulis et al.
Molecular cancer therapeutics, 8(5), 1197-1206 (2009-05-07)
Here, we report on the organic arsenical darinaparsin (ZIO-101, S-dimethylarsino-glutathione) and its anti-myeloma activity compared with inorganic arsenic trioxide. Darinaparsin induced apoptosis in multiple myeloma cell lines in a dose-dependent manner, and the addition of N-acetylcysteine, which increases intracellular glutathione
NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons.
Hughes, R; Kristiansen, M; Lassot, I; Desagher, S; Mantovani, R; Ham, J
Cell Death and Differentiation null
Nicola J Darling et al.
PloS one, 12(9), e0184907-e0184907 (2017-09-21)
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed through
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