8.52345

Fmoc-Gla(OtBu)2-OH

Novabiochem^®

• Synonyme(s) : Fmoc-Gla(OtBu)2-OH, Fmoc-γ-carboxy-Glu(OtBu) ₂-OH
• Formule empirique (notation de Hill) : C₂₉H₃₅NO₈
• Numéro CAS: 111662-64-7
• Poids moléculaire : 525.59
• Numéro MDL: MFCD00038770
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Forme: solid
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: carboxylic acid
• Température de stockage: 2-8°C
• Chaîne SMILES: N([C@@H](CC(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C29H35NO8/c1-28(2,3)37-25(33)21(26(34)38-29(4,5)6)15-23(24(31)32)30-27(35)36-16-22-19-13-9-7-11-17(19)18-12-8-10-14-20(18)22/h7-14,21-23H,15-16H2,1-6H3,(H,30,35)(H,31,32)/t23-/m0/s1
• Clé InChI: XJRUHYXXHXECDI-QHCPKHFHSA-N

Description

Description générale

Fmoc-Gla(OtBu)2-OH is a building block for the introduction of γ-carboxyglutamic acid (Gla). γ -Carboxylation of glutamic acid is a rare post-translational modification that occurs in blood coagulation factors and in some snake and cone snail venoms ^[1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] P. K. Bandyopadhyay (2002) Proc. Natl. Acad. Sci. USA, 99, 1264 .

Remarque sur l'analyse

Colour (visual): white to slight yellow to slight red
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.
European Union for cosmetic colour additives.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable