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Sigma-Aldrich

TLR3/dsRNA Complex Inhibitor

≥99% (HPLC), solid, TLR3/dsRNA complex inhibitor, Calbiochem®

Synonyme(s) :

TLR3/dsRNA Complex Inhibitor, ( R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

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About This Item

Formule empirique (notation de Hill):
C18H13ClFNO3S
Poids moléculaire :
377.82
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.28

product name

TLR3/dsRNA Complex Inhibitor, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.

Niveau de qualité

100

Pureté

≥99% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

white

Solubilité

DMSO: 50 mg/mL

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Description générale

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >>100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Cheng, K., et al. 2011. J. Am. Chem. Soc.133, 3764.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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