605225

Thrombospondin, Human Platelets

• Synonyme(s) : Thrombospondin protein
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥95% (SDS-PAGE)
• Niveau de qualité: 100
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: water: soluble
• Conditions d'expédition: wet ice
• Température de stockage: −70°C

Description

Description générale

Native thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by α-thrombin. An angiogenesis inhibitor that blocks the FGF-induced neovascularization of the rat cornea. An inducer of platelet aggregation. Synthesized by a number of different cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.

Native thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by a-thrombin. Inhibits FGF-induced neovascularization on rat cornea. An inducer of platelet aggregation. Synthesized by a number of cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.

Avertissement

Toxicity: Standard Handling (A)

Forme physique

Lyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.

Notes préparatoires

Please refer to lot-specific reconstitution volume on the vial label.

Prepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.

Autres remarques

Armstrong, L.C., et al. 2002. Mol. Biol. Cell13, 1893.
Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
Koch, A.E., et al. 1993. Pathobiology 61, 1.
Tolsma, S.S., et al. 1993. J. Cell Biol.122, 497.
Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA87, 6624.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1