513024-M

PD 151746

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.

• Synonyme(s) : PD 151746, 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
• Formule empirique (notation de Hill): C₁₁H₈FNO₂
• Numéro CAS: 179461-52-0
• Poids moléculaire : 205.19
• Numéro MDL: MFCD03453564
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: orange
• Solubilité: DMSO: 200 mg/mL; methanol: 5 mg/mL
• Température de stockage: −20°C
• InChI: 1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
• Clé InChI: HWMQHECFXSVZGN-KMKOMSMNSA-N

Description

Description générale

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for µ-calpain (Calpain I) over m-calpain (Calpain II) (K_i values, 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide induced apoptosis.

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (K_i values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.

Actions biochimiques/physiologiques

Primary Target
calpain-1

Target K_i: 260 nM against calpain-1

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Autres remarques

Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable