5.04815

Salmeterol Xinafoate

• Synonyme(s) : Salmeterol Xinafoate, (±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate, β₂-Adrenoceptor Agonist, Salmeterol Xinafoate
• Formule empirique (notation de Hill): C₂₅H₃₇NO₄ · C₁₁H₈O₃
• Numéro CAS: 94749-08-3
• Poids moléculaire : 603.75
• Numéro MDL: MFCD00897708
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Température de stockage: 10-30°C
• InChI: 1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14)
• Clé InChI: XTZNCVSCVHTPAI-UHFFFAOYSA-N

Description

Description générale

A potent and selective β₂-adrenoceptor agonist (EC₅₀ = 5.3 nM) that displays bronchodilator actions. Unlike other β₂- adrenoceptor agonists, Salmeterol binds to exo-site domain of β₂-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

A potent and selective ?₂-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other ?₂- adrenoceptor agonists, Salmeterol binds to exo-site domain of ?₂-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

Actions biochimiques/physiologiques

Primary Target
→₂-adrenoceptor

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Roberts, J., et al. 1999. Eur. Respir. J.14, 275.
Rennard, S., et al. 2001. Am. J. Respir. Crit. Care Med.163, 1087.
Akabane, H., et al. 2006. Allergol. Int.55, 387.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable