5.04345

BX471

• Synonyme(s) : BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
• Formule empirique (notation de Hill): C₂₁H₂₄ClFN₄O₃
• Numéro CAS: 217645-70-0
• Poids moléculaire : 434.89
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Puissance: 1-5 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to beige
• Solubilité: DMSO: ≥25 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
• Clé InChI: XQYASZNUFDVMFH-CQSZACIVSA-N

Description

Description générale

An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (K_i = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.

Actions biochimiques/physiologiques

Primary Target
CCR1

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.

Reuss, R., et al. 2010. Mult Scler.16, 366.

Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.

Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.

Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°C): Not applicable