480030

NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control

A cell-permeable Antennapedia-NBD mutated fusion peptide analog of NEMO-Binding Domain Binding Peptide that serves as a negative control.

• Synonyme(s) : NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control, DRQIKIWFQNRRMKWKK-TALDASALQTE, NBD-Binding Peptide, Cell-Permeable, Negative Control
• Formule empirique (notation de Hill) : C₁₅₄H₂₄₉N₄₇O₄₂S
• Poids moléculaire : 3462.98
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: off-white
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A cell-permeable Antennapedia-NBD mutated (Trp⁷³⁹ and Trp⁷⁴¹ replaced with Ala) fusion peptide analog of NEMO-Binding Domain Binding Peptide (Cat. No. 480025) that serves as a negative control. Shown to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.

A cell-permeable, Antennapedia-NBD mutated (Trp⁷³⁹ → Ala and Trp⁷⁴¹ → Ala) fusion peptide analog of NEMO-Binding Domain Binding peptide (Cat. No. 480025) that serves as a negative control. Reported to be defective in binding to NEMO. Does not affect the TNF-α-induced phosphorylation of c-Jun or DNA binding of the transcription factor Oct-1.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Negative control defective in binding to NEMO

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Séquence

H₂N-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Ala-Ser-Ala-Leu-Gln-Thr-Glu-OH

Autres remarques

Jimi, E., et al. 2004. Nat. Med., 10, 617.
May, M.J., et al. 2000. Science289, 1550.

This peptide will precipitate when added to tissue culture medium even at 100 µM concentrations; however, sufficient material will stay in solution to permeate cells.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable