444247

MMP Inhibitor II

The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP Inhibitor II, N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
• Formule empirique (notation de Hill): C₂₁H₂₇N₃O₈S₂
• Numéro CAS: 203915-59-7
• Poids moléculaire : 513.58
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white
• Solubilité: DMSO: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C21H27N3O8S2/c1-21(2)13-23(33(27,28)17-9-5-15(31-3)6-10-17)20(19(25)22-26)24(14-21)34(29,30)18-11-7-16(32-4)8-12-18/h5-12,20,26H,13-14H2,1-4H3,(H,22,25)
• Clé InChI: MCSWSPNUKWMZHM-UHFFFAOYSA-N

Description

Description générale

A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

A potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

Actions biochimiques/physiologiques

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Requires vigorous vortexing for 60 seconds to completely solubilize the product.

Autres remarques

Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable