444221

MMP-1/MMP-9 Substrate, Fluorogenic

An excellent quenched fluorescence substrate for MMP-1 and MMP-9.

• Synonyme(s) : MMP-1/MMP-9 Substrate, Fluorogenic
• Formule empirique (notation de Hill) : C₄₉H₆₈N₁₄O₁₂S
• Poids moléculaire : 1077.22
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: 50% acetic acid: 10 mg/mL
• Fluorescence: λ_ex ~365 nm; λ_em ~450 nm
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

An excellent quenched fluorescence substrate for MMP-1 and MMP-9 (excitation maximum: 365 nm; emission maximum: 450 nm). Both enzymes cleave this substrate between Gly and Cys(Me), liberating a fluorescent cleavage product. Suitable for inhibitor screening and determining K_i values. Excitation max: ~365 nm; emission max: ~450 nm.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
MMP-1, MMP-9

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Séquence

{DNP-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH₂[Cha = β-cyclohexylalanyl; Abz = 2-aminobenzoyl (anthraniloyl)]

Autres remarques

Bickett, D.M., et al. 1993. Anal. Biochem. 212, 58.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable