219556

Ceranib-2

A cell-permeable, potent inhibitor of ceramidase (IC₅₀ = 28 mM) with anti-proliferative and proapoptotic properties.

• Synonyme(s) : Ceranib-2, Ceranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III
• Formule empirique (notation de Hill): C₂₅H₁₉NO₃
• Poids moléculaire : 381.42
• Numéro MDL: MFCD25977826
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 100 mg/mL, clear, pale yellow
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(N1)C(C(/C=C/C2=CC=C(OC)C=C2)=O)=C(C3=CC=CC=C3)C4=C1C=CC=C4

Description

Description générale

A cell-permeable, potent inhibitor of ceramidase (IC₅₀ = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC₅₀ = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Draper, J., et al. 2011, Mol. Cancer Ther.10, 2052.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3