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P51559

Sigma-Aldrich

Propionyl chloride

98%

Synonyme(s) :

Chloro ethyl ketone, Ethyl chloroform, Propionic acid chloride, Prorionyl chloride

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25 G
40.70 CHF
500 G
59.10 CHF

40.70 CHF

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25 G
40.70 CHF
500 G
59.10 CHF

About This Item

Formule linéaire :
CH3CH2COCl
Numéro CAS:
79-03-8
Poids moléculaire :
92.52
Beilstein:
385632
Numéro CE :
201-170-0
Numéro MDL:
MFCD00000745
Code UNSPSC :
12352100
ID de substance PubChem :
24898602
Nomenclature NACRES :
NA.22

40.70 CHF

Check Cart for Availability
Devis pour commande en gros

Densité de vapeur

3.2 (vs air)

Essai

98%

Indice de réfraction

n20/D 1.404 (lit.)

pb

77-79 °C (lit.)

Pf

−94 °C

Densité

1.059 g/mL at 25 °C (lit.)

Chaîne SMILES 

CCC(Cl)=O

InChI

1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3

Clé InChI

RZWZRACFZGVKFM-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Propionyl chloride is an important chemical intermediate used to synthesize various propionic acid derivatives.

Application

Propionyl chloride can be used as an acylating agent:
  • To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.[1]

It can also be used:
  • For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.[2]
  • In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.[3]

Pictogrammes

FlameSkull and crossbonesCorrosion
GHS02,GHS06,GHS05

Mention d'avertissement

Danger

Mentions de danger

H225,H302,H314,H331

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Risques supp

EUH014

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

42.8 °F - closed cup

Point d'éclair (°C)

6 °C - closed cup

Équipement de protection individuelle

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificats d'analyse (COA)

Lot/Batch Number
0000185870
0000178015
0000178015
0000185870
STBK0071

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Joanna Kurczewska et al.
International journal of pharmaceutics, 486(1-2), 226-231 (2015-04-07)
Vancomycin was immobilized on three different organically functionalized silicas. The materials obtained were used for a controlled release of the antibiotic. The influence of the type of chemical bond on the in vitro drug release was investigated. A weak ionic
Acylation of aromatic compounds using moisture insensitive InCl3 impregnated mesoporous Si-MCM-41 catalyst
Choudhary VR, et al.
Tetrahedron Letters, 43(6), 1105-1107 (2002)
The propanoate ester of (2-hydroxypropyl) cellulose: a thermotropic cholesteric polymer that reflects visible light at ambient temperatures
Tseng SL, et L.
Macromolecules, 15(5), 1262-1264 (1982)
Douglas T Durig et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(7), 1481-1504 (2004-05-19)
Variable temperature (-60 to -100 degrees C) studies of the infrared spectra (3500-400 cm(-1)) of propionyl fluoride (CH3CH2CFO) and 2-methylpropionyl fluoride ((CH3)2CHCFO), dissolved in liquid xenon have been recorded. From these data, the enthalpy difference has been determined to be
Komal M Vyas et al.
Chemico-biological interactions, 240, 250-266 (2015-09-06)
Pyrazolone based metal complexes have strong bio-activity but the anti-cancer mechanism of these derivatives is not fully understood. In recent years, Cu(II) complexes have attracted the interest of researchers increasingly because of their high antitumor activities that are usually related
Afficher tous les articles scientifiques apparentés

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How to do assy by titration with naoh solution

    1 answer

    1. This product is tested by silver nitrate titration. The method is considered proprietary, the link below describes the general principle and offers a basic protocol:
      https://www.canterbury.ac.nz/media/documents/science-outreach/chloride_volhard.pdf
      Please refer to the literature for sodium hydroxide methods. The reference below may be helpful.
      https://www.sciencedirect.com/science/article/abs/pii/B9780124115187000056

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