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P21005

Sigma-Aldrich

4-Phenylbutyric acid

99%

Synonyme(s) :

γ-Phenylbutanoic acid, ψ-Phenylbutanoic acid, 4-Phenyl-n-butyric acid, 4-Phenylbutanoic acid, Benzenebutyric acid

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25 G
63.20 CHF
100 G
146.00 CHF

63.20 CHF

Date d'expédition estimée le29 mars 2025

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25 G
63.20 CHF
100 G
146.00 CHF

About This Item

Formule linéaire :
C6H5(CH2)3COOH
Numéro CAS:
1821-12-1
Poids moléculaire :
164.20
Beilstein:
638180
Numéro CE :
217-341-8
Numéro MDL:
MFCD00004403
Code UNSPSC :
12352100
ID de substance PubChem :
24898272
Nomenclature NACRES :
NA.22
Forme:
crystals
Essai:
99%

63.20 CHF

Date d'expédition estimée le29 mars 2025

Devis pour commande en gros

Niveau de qualité

200

Essai

99%

Forme

crystals

pb

165 °C/10 mmHg (lit.)

Pf

49-51 °C (lit.)

Chaîne SMILES 

OC(=O)CCCc1ccccc1

InChI

1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)

Clé InChI

OBKXEAXTFZPCHS-UHFFFAOYSA-N

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Description générale

4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders.[1]

Application

4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).[2]
It can also be used as a reactant in the synthesis of:
  • 1-Tetralone using Lewis acid catalyst.[3]
  • 4,N-diphenylbutyramide.[4]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
STBL4735
STBL2413
STBL1540
STBK6730
STBK9779

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Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

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Les clients ont également consulté

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Retro-2 ≥98% (HPLC)

Sigma-Aldrich

SML1085

Retro-2

4-PHENYLBUTANOYL CHLORIDE AldrichCPR

PH000271

4-PHENYLBUTANOYL CHLORIDE

DBeQ ≥98% (HPLC)

Sigma-Aldrich

SML0031

DBeQ

3-Phenylbutyric acid 98%

Sigma-Aldrich

116807

3-Phenylbutyric acid

2-Phenylbutyric acid 98%

Sigma-Aldrich

P20955

2-Phenylbutyric acid

methyl 4-phenylbutanoate AldrichCPR

PH010421

methyl 4-phenylbutanoate

Thapsigargine ≥98% (HPLC), solid film

Sigma-Aldrich

T9033

Thapsigargine

Induction of apoptosis coupled to endoplasmic reticulum stress through regulation of CHOP and JNK in bone marrow mesenchymal stem cells from patients with systemic lupus erythematosus
Guo G, et al.
Journal of immunology research (2015)
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
Kolb PS, et al.
The International Journal of Biochemistry & Cell Biology, 61, 45-52 (2015)
Clean, reusable and low cost heterogeneous catalyst for amide synthesis
Comerford JW, et al.
Chemical Communications (Cambridge, England), 18(21), 2562-2564 (2009)
Synthesis of 1-tetralones by intramolecular Friedel?Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts
Cui DM, et al.
Tetrahedron Letters, 44(21), 4007-4010 (2003)
Yu-Yang Ma et al.
Acta pharmacologica Sinica, 41(3), 404-414 (2019-11-09)
Xanthatin is a natural sesquiterpene lactone purified from Xanthium strumarium L., which has shown prominent antitumor activity against a variety of cancer cells. In the current study, we investigated the effect of xanthatin on the growth of glioma cells in
Afficher tous les articles scientifiques apparentés

Questions

1–6 of 6 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to conserve the powder ?

    1 answer

    1. This material is quite stable in the original sealed container. As listed in the Safety Data Sheet, under SECTION 7, the product may be stored at ambient temperature, tightly sealed, and in a dry environment.

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  4. What is the solubility of the product 4-Phenylbutyric acid, P21005?

    1 answer

    1. The water solubility of 4-phenylbutyric acid at 40 ºC is 5.3 g/L.

      Helpful?

  5. Hello, this reference is suitable for cell culture experiments?

    1 answer

    1. This product is not specified for cell culture use. Kindly review the following citation in which it was cited to treat cells in culture:
      Eigner K, Filik Y, Mark F, Schütz B, Klambauer G, Moriggl R, Hengstschläger M, Stangl H, Mikula M, Röhrl C. The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone. Sci Rep. 2017 Dec 13;7(1):17498. doi: 10.1038/s41598-017-17888-9. PMID: 29235576; PMCID: PMC5727496.

      Helpful?

  6. Hi, what is the solubility and in what?

    1 answer

    1. This product is not tested for solubility, however, various literature sources cite the following:
      0.010M in water
      3.670M in toluene
      4.800M in methanol
      4.130M in diethyl ether
      4.040M in chloroform
      0.500M in 1-hexanol
      This information has not been validated.

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