934577
Microneedle template
10x10 array, H 700 μm, base size 200 μm, 500 µm pitch
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
44111809
Produits recommandés
Hauteur
700 μm
Taille de la base
200 μm
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
Description générale
Microneedles are a platform for transdermal drug delivery. The advantages of microneedles include the delivery of large molecules, painless and less invasive administration of the active pharmaceutical ingredient (API), ease of administration, and improved drug delivery including dose, delivery rate and efficacy. Microneedles are also effective for vaccine delivery due to the abundance of immune cells in the dermis. These microneedle templates can be used to make reproducible and high quality microneedle patches for a variety of therapeutics.
Application
Transdermal delivery of a variety to therapeutics including:
- Nucleic acid delivery
- Vaccine delivery
- Protein or peptide delivery
- Small molecule delivery
Caractéristiques et avantages
Microneedle templates are exclusively made for producing dissolvable microneedle patches with excellent quality and repeatability. These templates are made of silicone rubber which is extremely durable, and chemical and heat resistant.
Propriétés physiques
Microneedle template properties:
- Silicone Template
- Material: PDMS
- Patch Size (D): 8mm x 8mm
- Array Size: 10 x 10
- Needle Height (A): 700 µm
- Needle Base (B): 200 µm
- Needle Pitch (C): 500 µm
- Length of last microneedle cavity to the edge of the patch (F) can be calculated using the following formula: F = (patch size - [(n-1) x pitch)] / 2 where n = number of microneedles in one array
- Sterilization: Autoclave (optional)
- No. of use: repeated use if clean and stored properly
Autres remarques
Suggested instructions for use:
1. Ensure the microneedle template is clean by washing with mild soap and letting them air dry completely
2. Pipette a small quantity (50-100 µL) of the drug mixture onto the microneedle template
3. Subject the template to centrifugal force for >60 seconds to ensure that all microneedle cavities are completely filled. The speed and duration are proportional to the viscosity of the matrix material and the volume of microneedle cavities to fill. Complete filling can be confirmed by observing the microneedle cavities under microscope (20x). No air bubbles are present for complete filling.
1. Ensure the microneedle template is clean by washing with mild soap and letting them air dry completely
2. Pipette a small quantity (50-100 µL) of the drug mixture onto the microneedle template
3. Subject the template to centrifugal force for >60 seconds to ensure that all microneedle cavities are completely filled. The speed and duration are proportional to the viscosity of the matrix material and the volume of microneedle cavities to fill. Complete filling can be confirmed by observing the microneedle cavities under microscope (20x). No air bubbles are present for complete filling.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Ying Hao et al.
Journal of biomedical nanotechnology, 13(12), 1581-1597 (2018-03-02)
A microneedle (MN) is a micron-sized needle with a height of 10-2000 μm and a width of 10-50 μm, which can penetrate through the epidermis layer to dermal tissue directly without pain. Microneedles are widely used in transdermal drug delivery
Ziad Sartawi et al.
Journal of controlled release : official journal of the Controlled Release Society, 348, 186-205 (2022-06-07)
Microneedles are a rapidly developing method for the transdermal delivery of therapeutic compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function by penetrating the stratum corneum layer of the skin producing a microchannel through which therapeutic agents
Jie Xu et al.
Molecules (Basel, Switzerland), 26(19), 5912-5912 (2021-10-14)
A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The
Ipshita Menon et al.
Micromachines, 12(4) (2021-05-01)
Transdermal vaccination route using biodegradable microneedles is a rapidly progressing field of research and applications. The fear of painful needles is one of the primary reasons most people avoid getting vaccinated. Therefore, developing an alternative pain-free method of vaccination using
Tejashree Waghule et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1249-1258 (2018-12-16)
The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum layer of the skin, which serves
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique