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803561

Sigma-Aldrich

BMOE (bis-maleimidoethane)

Synonyme(s) :

1,1′-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), N,N′-Ethylenebismaleimide, BMOE, Ethylenebismaleimide

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About This Item

Formule empirique (notation de Hill):
C10H8N2O4
Numéro CAS:
5132-30-9
Poids moléculaire :
220.18
Numéro MDL:
MFCD00458699
Code UNSPSC :
12352200
ID de substance PubChem :
329768818
Nomenclature NACRES :
NA.22

Forme

powder

Poids mol.

220.18

Pertinence de la réaction

reagent type: cross-linking reagent

Conditions de stockage

desiccated

Solubilité

DMSO or DMF: soluble

Conditions d'expédition

ambient

Température de stockage

2-8°C

Chaîne SMILES 

O=C(C=CC1=O)N1CCN2C(C=CC2=O)=O

InChI

1S/C10H8N2O4/c13-7-1-2-8(14)11(7)5-6-12-9(15)3-4-10(12)16/h1-4H,5-6H2

Clé InChI

PUKLCKVOVCZYKF-UHFFFAOYSA-N

Description générale

BMOE, BMB and BMH are homobifunctional, maleimide crosslinkers for conjugation between sulfhydryl groups (-SH). Such bismaleimide crosslinkers are commonly used to explore and characterize protein structure (i.e., oligomerization) or protein interactions. Because BMOE, BMB and BMH have the same reactivity but differ in length, the relative success of these three reagents in forming crosslinks between sites in a protein oligomer or interaction can assist in determining intra- and intermolecular distances.

Caractéristiques et avantages

  • Reactive groups: maleimide (both ends)
  • Reactive towards: sulfhydryl groups
  • Short (8.0Å), sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 7-atom spacer arm
  • Shortest bismaleimide crosslinker available for close proximity crosslinking
  • Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
  • Noncleavable

Attention

This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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