158828
2-Mercapto-4(3H)-quinazolinone
97%
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About This Item
Formule empirique (notation de Hill) :
C8H6N2OS
Numéro CAS:
Poids moléculaire :
178.21
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352100
ID de substance PubChem :
Nomenclature NACRES :
NA.22
Produits recommandés
Essai
97%
Forme
liquid
Pf
>300 °C (lit.)
Chaîne SMILES
SC1=Nc2ccccc2C(=O)N1
InChI
1S/C8H6N2OS/c11-7-5-3-1-2-4-6(5)9-8(12)10-7/h1-4H,(H2,9,10,11,12)
Clé InChI
PUPFOFVEHDNUJU-UHFFFAOYSA-N
Description générale
The FTIR and FT-Raman spectra of 2-mercapto-4(3H) quinazolinone has been studied. Alkylation of 2-mercapto-4(3H)-quinazolinone has been reported.
Application
2-Mercapto-4(3H)-quinazolinone was employed as a modifier for the carbon paste electrode, for voltammetric determination of mercury. It was used in the synthesis of 4-quinazolinone derivatives, inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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Stripping voltammetric determination of trace amounts of mercury using a carbon paste electrode modified with 2-mercapto-4 (3H)-quinazolinone.
Cai X, et al.
Microchimica Acta, 112(1-4), 135-146 (1993)
Synthesis and study of new 4-quinazolinone inhibitors of the DNA repair enzyme poly (ADP-ribose) polymerase (PARP).
Kulcsar G, et al.
ARKIVOC (Gainesville, FL, United States), 121, 131-131 (2003)
N Prabavathi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 129, 572-583 (2014-05-13)
The FTIR and FT-Raman spectra of 2-mercapto-4(3H) quinazolinone have been recorded in the region 4000-450 and 4000-100 cm(-1), respectively. The optimized geometry, frequency and intensity of the vibrational bands of 2-mercapto-4(3H) quinazolinone (2MQ) were obtained by the density functional theory
Monize M da Silva et al.
Dalton transactions (Cambridge, England : 2003), 48(39), 14885-14897 (2019-09-27)
Herein we discuss five ruthenium(ii) complexes with good cytotoxicity against cancer cells. These complexes are named [Ru(tzdt)(bipy)(dppb)]PF6 (1), [Ru(mmi)(bipy)(dppb)]PF6 (2), [Ru(dmp)(bipy)(dppb)]PF6 (3), [Ru(mpca)(bipy)(dppb)]PF6 (4) and [Ru(2mq)(bipy)(dppb)]PF6 (5), where tzdt = 1,3-thiazolidine-2-thione, mmi = mercapto-1-methyl-imidazole, dmp = 4,6-diamino-2-mercaptopyrimidine, mpca = 6-mercaptopyridine-3-carboxylic
Tomás Lombardo et al.
Basic & clinical pharmacology & toxicology, 122(5), 489-500 (2017-12-06)
Collapse of the mitochondrial membrane potential (MMP) is often considered the initiation of regulated cell death (RCD). Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) is an uncoupler of the electron transport chain (ETC) that facilitates the translocation of protons into the mitochondrial matrix
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